Safety Assessment of Dimethiconol and Its Esters and Reaction Products as Used in Cosmetics

Wilbur Johnson; Bart Heldreth; Wilma F. Bergfeld; Donald V. Belsito; Ronald A. Hill; Curtis D. Klaassen; Daniel C. Liebler; James G. Marks; Ronald C. Shank; Thomas J. Slaga; Paul W. Snyder; F. Alan Andersen

doi:10.1177/1091581817739429

Safety Assessment of Dimethiconol and Its Esters and Reaction Products as Used in Cosmetics

Wilbur Johnson, Bart Heldreth, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen

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Abstract

Dimethiconol and its esters and reaction products are used in cosmetics as either skin-conditioning agents or hair-conditioning agents. The Cosmetic Ingredient Review (CIR) Expert Panel reviewed relevant data and concluded that these ingredients are safe in the present practices of use and concentration described in this safety assessment. While there is an absence of data on reproductive and developmental toxicity and limited tumorigenicity and toxicokinetics data, the Panel reasoned that these ingredients would not be absorbed through the skin, obviating concern over potential reproductive and developmental toxicity or carcinogenicity.

Original language	English (US)
Pages (from-to)	31S-50S
Journal	International journal of toxicology
Volume	36
Issue number	3_suppl
DOIs	https://doi.org/10.1177/1091581817739429
State	Published - Nov 1 2017

All Science Journal Classification (ASJC) codes

Toxicology

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10.1177/1091581817739429

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Johnson, W., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., Marks, J. G., Shank, R. C., Slaga, T. J., Snyder, P. W., & Andersen, F. A. (2017). Safety Assessment of Dimethiconol and Its Esters and Reaction Products as Used in Cosmetics. International journal of toxicology, 36(3_suppl), 31S-50S. https://doi.org/10.1177/1091581817739429

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title = "Safety Assessment of Dimethiconol and Its Esters and Reaction Products as Used in Cosmetics",

abstract = "Dimethiconol and its esters and reaction products are used in cosmetics as either skin-conditioning agents or hair-conditioning agents. The Cosmetic Ingredient Review (CIR) Expert Panel reviewed relevant data and concluded that these ingredients are safe in the present practices of use and concentration described in this safety assessment. While there is an absence of data on reproductive and developmental toxicity and limited tumorigenicity and toxicokinetics data, the Panel reasoned that these ingredients would not be absorbed through the skin, obviating concern over potential reproductive and developmental toxicity or carcinogenicity.",

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AU - Heldreth, Bart

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AU - Hill, Ronald A.

AU - Klaassen, Curtis D.

AU - Liebler, Daniel C.

AU - Marks, James G.

AU - Shank, Ronald C.

AU - Slaga, Thomas J.

AU - Snyder, Paul W.

AU - Andersen, F. Alan

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AB - Dimethiconol and its esters and reaction products are used in cosmetics as either skin-conditioning agents or hair-conditioning agents. The Cosmetic Ingredient Review (CIR) Expert Panel reviewed relevant data and concluded that these ingredients are safe in the present practices of use and concentration described in this safety assessment. While there is an absence of data on reproductive and developmental toxicity and limited tumorigenicity and toxicokinetics data, the Panel reasoned that these ingredients would not be absorbed through the skin, obviating concern over potential reproductive and developmental toxicity or carcinogenicity.

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Safety Assessment of Dimethiconol and Its Esters and Reaction Products as Used in Cosmetics

Abstract

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