Safety Assessment of Panax spp Root-Derived Ingredients as Used in Cosmetics

Lillian C. Becker, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen, Lillian J. Gill

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of 13 Panax spp root-derived ingredients as used in cosmetics. Panax €spp€ indicates that multiple species within the genus are used in cosmetics, but not all species within that genus. Four species are being considered in this safety assessment. These ingredients function mostly as skin-conditioning agents - miscellaneous, fragrance ingredients, skin-conditioning agents - humectant, skin-conditioning agents - emollient, and cosmetic astringents. The Panel reviewed available data related to these ingredients and addressed the issue of pulegone, a constituent of these ingredients and other ingredients, such as peppermint oil. The Panel concluded that these Panax spp root-derived ingredients are safe in the practices of use and concentration as given in this safety assessment.

Original languageEnglish (US)
Pages (from-to)5S-42S
JournalInternational journal of toxicology
StatePublished - Nov 1 2015

All Science Journal Classification (ASJC) codes

  • Toxicology


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