Safety Assessment of Tin(IV) Oxide as Used in Cosmetics

Wilbur Johnson; Wilma F. Bergfeld; Donald V. Belsito; Ronald A. Hill; Curtis D. Klaassen; Daniel C. Liebler; James G. Marks; Ronald C. Shank; Thomas J. Slaga; Paul W. Snyder; F. Alan Andersen

doi:10.1177/1091581814559309

Safety Assessment of Tin(IV) Oxide as Used in Cosmetics

Wilbur Johnson
, Wilma F. Bergfeld
, Donald V. Belsito
, Ronald A. Hill
, Curtis D. Klaassen
, Daniel C. Liebler
, James G. Marks
, Ronald C. Shank
, Thomas J. Slaga
, Paul W. Snyder
, F. Alan Andersen

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Tin(IV) oxide functions as an abrasive, bulking, and opacifying agent in cosmetic products and is used at concentrations up to 0.4% in rinse-off products and up to 1.3% in leave-on products. The Cosmetic Ingredient Review Expert Panel (Panel) noted that tin(IV) oxide is a water-insoluble inorganic metal compound and should not be percutaneously absorbed; therefore, systemic exposure is not likely. Studies of dermal application of tin(IV) oxide were considered to determine toxicity at the site of application. The Panel concluded that tin(IV) oxide is safe in the present practices of use and concentration.

Original language	English (US)
Pages (from-to)	40S-46S
Journal	International journal of toxicology
Volume	33
DOIs	https://doi.org/10.1177/1091581814559309
State	Published - Nov 2014

All Science Journal Classification (ASJC) codes

Toxicology

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10.1177/1091581814559309

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@article{2015ea11af274351a0d4d60ef5ad8402,

title = "Safety Assessment of Tin(IV) Oxide as Used in Cosmetics",

abstract = "Tin(IV) oxide functions as an abrasive, bulking, and opacifying agent in cosmetic products and is used at concentrations up to 0.4\% in rinse-off products and up to 1.3\% in leave-on products. The Cosmetic Ingredient Review Expert Panel (Panel) noted that tin(IV) oxide is a water-insoluble inorganic metal compound and should not be percutaneously absorbed; therefore, systemic exposure is not likely. Studies of dermal application of tin(IV) oxide were considered to determine toxicity at the site of application. The Panel concluded that tin(IV) oxide is safe in the present practices of use and concentration.",

author = "Wilbur Johnson and Bergfeld, \{Wilma F.\} and Belsito, \{Donald V.\} and Hill, \{Ronald A.\} and Klaassen, \{Curtis D.\} and Liebler, \{Daniel C.\} and Marks, \{James G.\} and Shank, \{Ronald C.\} and Slaga, \{Thomas J.\} and Snyder, \{Paul W.\} and Andersen, \{F. Alan\}",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The articles in this supplement were sponsored by the Cosmetic Ingredient Review. The Cosmetic Ingredient Review is financially supported by the Personal Care Products Council.",

year = "2014",

month = nov,

doi = "10.1177/1091581814559309",

language = "English (US)",

volume = "33",

pages = "40S--46S",

journal = "International journal of toxicology",

issn = "1091-5818",

publisher = "SAGE Publications Inc.",

}

TY - JOUR

T1 - Safety Assessment of Tin(IV) Oxide as Used in Cosmetics

AU - Johnson, Wilbur

AU - Bergfeld, Wilma F.

AU - Belsito, Donald V.

AU - Hill, Ronald A.

AU - Klaassen, Curtis D.

AU - Liebler, Daniel C.

AU - Marks, James G.

AU - Shank, Ronald C.

AU - Slaga, Thomas J.

AU - Snyder, Paul W.

AU - Andersen, F. Alan

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The articles in this supplement were sponsored by the Cosmetic Ingredient Review. The Cosmetic Ingredient Review is financially supported by the Personal Care Products Council.

PY - 2014/11

Y1 - 2014/11

N2 - Tin(IV) oxide functions as an abrasive, bulking, and opacifying agent in cosmetic products and is used at concentrations up to 0.4% in rinse-off products and up to 1.3% in leave-on products. The Cosmetic Ingredient Review Expert Panel (Panel) noted that tin(IV) oxide is a water-insoluble inorganic metal compound and should not be percutaneously absorbed; therefore, systemic exposure is not likely. Studies of dermal application of tin(IV) oxide were considered to determine toxicity at the site of application. The Panel concluded that tin(IV) oxide is safe in the present practices of use and concentration.

AB - Tin(IV) oxide functions as an abrasive, bulking, and opacifying agent in cosmetic products and is used at concentrations up to 0.4% in rinse-off products and up to 1.3% in leave-on products. The Cosmetic Ingredient Review Expert Panel (Panel) noted that tin(IV) oxide is a water-insoluble inorganic metal compound and should not be percutaneously absorbed; therefore, systemic exposure is not likely. Studies of dermal application of tin(IV) oxide were considered to determine toxicity at the site of application. The Panel concluded that tin(IV) oxide is safe in the present practices of use and concentration.

UR - https://www.scopus.com/pages/publications/84938943649

UR - https://www.scopus.com/pages/publications/84938943649#tab=citedBy

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DO - 10.1177/1091581814559309

M3 - Article

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AN - SCOPUS:84938943649

SN - 1091-5818

VL - 33

SP - 40S-46S

JO - International journal of toxicology

JF - International journal of toxicology

ER -

Safety Assessment of Tin(IV) Oxide as Used in Cosmetics

Abstract

All Science Journal Classification (ASJC) codes

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