Safety Assessment of Trialkyl Trimellitates as Used in Cosmetics

Monice M. Fiume; Wilma F. Bergfeld; Donald V. Belsito; Ronald A. Hill; Curtis D. Klaassen; Daniel C. Liebler; James G. Marks; Ronald C. Shank; Thomas J. Slaga; Paul W. Snyder; Lillian J. Gill; Bart Heldreth

doi:10.1177/10915818231224248

Safety Assessment of Trialkyl Trimellitates as Used in Cosmetics

Monice M. Fiume, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Lillian J. Gill, Bart Heldreth

Research output: Contribution to journal › Article › peer-review

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 5 trialkyl trimellitates. These ingredients, which are all structurally related as alkyl esters of trimellitic acid, are reported to function in cosmetics as skin conditioning agents; 2 of the ingredients are also reported to function in cosmetics as plasticizers. The Panel reviewed the available data to determine the safety of these ingredients, and concluded that the trialkyl trimellitates are safe in the current practices of use and concentration when formulated to be non-irritating.

Original language	English (US)
Pages (from-to)	96S-120S
Journal	International journal of toxicology
Volume	43
Issue number	1_suppl
DOIs	https://doi.org/10.1177/10915818231224248
State	Published - Feb 2024

All Science Journal Classification (ASJC) codes

Toxicology

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10.1177/10915818231224248

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title = "Safety Assessment of Trialkyl Trimellitates as Used in Cosmetics",

abstract = "The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 5 trialkyl trimellitates. These ingredients, which are all structurally related as alkyl esters of trimellitic acid, are reported to function in cosmetics as skin conditioning agents; 2 of the ingredients are also reported to function in cosmetics as plasticizers. The Panel reviewed the available data to determine the safety of these ingredients, and concluded that the trialkyl trimellitates are safe in the current practices of use and concentration when formulated to be non-irritating.",

author = "Fiume, {Monice M.} and Bergfeld, {Wilma F.} and Belsito, {Donald V.} and Hill, {Ronald A.} and Klaassen, {Curtis D.} and Liebler, {Daniel C.} and Marks, {James G.} and Shank, {Ronald C.} and Slaga, {Thomas J.} and Snyder, {Paul W.} and Gill, {Lillian J.} and Bart Heldreth",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2023.",

year = "2024",

month = feb,

doi = "10.1177/10915818231224248",

language = "English (US)",

volume = "43",

pages = "96S--120S",

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AU - Fiume, Monice M.

AU - Bergfeld, Wilma F.

AU - Belsito, Donald V.

AU - Hill, Ronald A.

AU - Klaassen, Curtis D.

AU - Liebler, Daniel C.

AU - Marks, James G.

AU - Shank, Ronald C.

AU - Slaga, Thomas J.

AU - Snyder, Paul W.

AU - Gill, Lillian J.

AU - Heldreth, Bart

PY - 2024/2

Y1 - 2024/2

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AB - The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of 5 trialkyl trimellitates. These ingredients, which are all structurally related as alkyl esters of trimellitic acid, are reported to function in cosmetics as skin conditioning agents; 2 of the ingredients are also reported to function in cosmetics as plasticizers. The Panel reviewed the available data to determine the safety of these ingredients, and concluded that the trialkyl trimellitates are safe in the current practices of use and concentration when formulated to be non-irritating.

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JO - International journal of toxicology

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IS - 1_suppl

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Safety Assessment of Trialkyl Trimellitates as Used in Cosmetics

Abstract

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