TY - JOUR
T1 - Safety, effectiveness and exposure-response of micafungin in infants
T2 - Application of an established pharmacokinetics model to electronic health records
AU - Rivera-Chaparro, Nazario D.
AU - Ericson, Jessica
AU - Wu, Huali
AU - Smith, P. Brian
AU - Clark, Reese H.
AU - Benjamin, Daniel K.
AU - Cohen-Wolkowiez, Michael
AU - Greenberg, Rachel G.
N1 - Publisher Copyright:
© 2018 Wolters Kluwer Health, Inc.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Micafungin is used off-label in the United States to treat invasive candidiasis in neonates. We used an established pharmacokinetic model to determine micafungin exposures for 46 courses in 39 hospitalized infants. In this small cohort of infants, micafungin exposure was not associated with laboratory markers of liver toxicity, death or failure of microbiologic clearance.
AB - Micafungin is used off-label in the United States to treat invasive candidiasis in neonates. We used an established pharmacokinetic model to determine micafungin exposures for 46 courses in 39 hospitalized infants. In this small cohort of infants, micafungin exposure was not associated with laboratory markers of liver toxicity, death or failure of microbiologic clearance.
UR - http://www.scopus.com/inward/record.url?scp=85059883824&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059883824&partnerID=8YFLogxK
U2 - 10.1097/INF.0000000000002045
DO - 10.1097/INF.0000000000002045
M3 - Article
C2 - 29601453
AN - SCOPUS:85059883824
SN - 0891-3668
VL - 38
SP - e26-e28
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
IS - 2
ER -
