Safety issues related to intravenous contrast agent use in magnetic resonance imaging

Skorn Ponrartana, Michael M. Moore, Sherwin S. Chan, Teresa Victoria, Jonathan R. Dillman, Govind B. Chavhan

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Gadolinium-based contrast agents (GBCAs) have been used to improve image quality of MRI examinations for decades and have an excellent overall safety record. However, there are well-documented risks associated with GBCAs and our understanding and management of these risks continue to evolve. The purpose of this review is to discuss the safety of GBCAs used in MRI in adult and pediatric populations. We focus particular attention on acute adverse reactions, nephrogenic systemic fibrosis and gadolinium deposition. We also discuss the non-GBCA MRI contrast agent ferumoxytol, which is increasing in use and has its own risk profile. Finally, we identify special populations at higher risk of harm from GBCA administration.

Original languageEnglish (US)
Pages (from-to)736-747
Number of pages12
JournalPediatric Radiology
Issue number5
StatePublished - May 2021

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Radiology Nuclear Medicine and imaging


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