TY - JOUR
T1 - Salivary hydrogen peroxide produced by holding or chewing green tea in the oral cavity
AU - Lambert, Joshua D.
AU - Kwon, Seok Joo
AU - Hong, Jungil
AU - Yang, Chung S.
N1 - Funding Information:
Correspondence: J. D. Lambert, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Rd, Piscataway, NJ 08854, USA. Fax: 1 732 445 0687. E-mail: [email protected] *Supported by National Institutes of Health Grant CA88961 (to CSY) and American Institute for Cancer Research Grant 05A047 (to JDL)
PY - 2007
Y1 - 2007
N2 - Tea (Camellia sinensis) catechins have been studied for disease prevention. These compounds undergo oxidation and produce H2 O2. We have previously shown that holding tea solution or chewing tea leaves generates high salivary catechin levels. Herein, we examined the generation of H2O2 in the oral cavity by green tea solution or leaves. Human volunteers holding green tea solution (0.1-0.6%) developed salivary H2O2 with CmaxO2 = 2.9-9.6 μM and AUCH0→∞ = 8.5-285.3 μMmin. Chewing 2 g green tea leaves produced higher levels of H2O2 (Cmax=31.2 μM, AUC0rarr;∞ = 1290.9 μM min). Salivary H2O2 correlated with catechin levels and with predicted levels of H2O2 (Cmax(expected) = 36 μM vs Cmax(determined) = 31.2 μM). Salivary H2O2 and catechin concentrations were similar to those that are biologically active in vitro. Catechin-generated H2O2 may, therefore, have a role in disease prevention by green tea.
AB - Tea (Camellia sinensis) catechins have been studied for disease prevention. These compounds undergo oxidation and produce H2 O2. We have previously shown that holding tea solution or chewing tea leaves generates high salivary catechin levels. Herein, we examined the generation of H2O2 in the oral cavity by green tea solution or leaves. Human volunteers holding green tea solution (0.1-0.6%) developed salivary H2O2 with CmaxO2 = 2.9-9.6 μM and AUCH0→∞ = 8.5-285.3 μMmin. Chewing 2 g green tea leaves produced higher levels of H2O2 (Cmax=31.2 μM, AUC0rarr;∞ = 1290.9 μM min). Salivary H2O2 correlated with catechin levels and with predicted levels of H2O2 (Cmax(expected) = 36 μM vs Cmax(determined) = 31.2 μM). Salivary H2O2 and catechin concentrations were similar to those that are biologically active in vitro. Catechin-generated H2O2 may, therefore, have a role in disease prevention by green tea.
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U2 - 10.1080/10715760601091659
DO - 10.1080/10715760601091659
M3 - Article
C2 - 17577746
AN - SCOPUS:34347258919
SN - 1071-5762
VL - 41
SP - 850
EP - 853
JO - Free Radical Research
JF - Free Radical Research
IS - 7
ER -
