TY - JOUR
T1 - Salivary nerve growth factor response to stress related to resilience
AU - Laurent, Heidemarie K.
AU - Laurent, Sean M.
AU - Granger, Douglas A.
N1 - Funding Information:
This research was supported by a Faculty Grant-in-Aid from the University of Wyoming and a Basic Research Grant from the College of Arts and Sciences at the University of Wyoming, both awarded to the first two authors. In the interest of full disclosure, we note that DAG is the Founder and Chief Strategy and Scientific Advisor at Salimetrics LLC (State College, PA) and Salivabio LLC (Baltimore, MD). DAG's relationships with these entities are managed by the policies of the Conflict of Interest Committee at the Johns Hopkins University and the Office of Research Integrity and Assurance at Arizona State University. Salimetrics donated the salivary sNGF assays used in this study.
PY - 2014/4/22
Y1 - 2014/4/22
N2 - Salivary nerve growth factor (sNGF) has recently been shown to respond to psychosocial stress, but little is known about how individual differences in this neurotrophic marker relate to stress vulnerability vs. resilience. This study followed up on these initial findings by examining sNGF responses to interpersonal stress in relation to both well-being and state/trait factors that determine the way a person approaches and is impacted by stress. Young adults (n=. 40) gave 5 saliva samples over the course of a laboratory session that involved an interpersonal conflict stressor, and all samples were assayed for sNGF. Participants also completed self-report measures of global well-being, stress appraisals before and following the conflict, and agency. Greater sNGF reactivity to conflict related to stronger appraisals of coping ability and agency. Post-conflict sNGF recovery related to lower anticipatory stress appraisals, and to higher agency and well-being. These results support the idea that dynamic sNGF responses are adaptive. Implications for the potential role of the neurotrophic system in stress resilience are discussed.
AB - Salivary nerve growth factor (sNGF) has recently been shown to respond to psychosocial stress, but little is known about how individual differences in this neurotrophic marker relate to stress vulnerability vs. resilience. This study followed up on these initial findings by examining sNGF responses to interpersonal stress in relation to both well-being and state/trait factors that determine the way a person approaches and is impacted by stress. Young adults (n=. 40) gave 5 saliva samples over the course of a laboratory session that involved an interpersonal conflict stressor, and all samples were assayed for sNGF. Participants also completed self-report measures of global well-being, stress appraisals before and following the conflict, and agency. Greater sNGF reactivity to conflict related to stronger appraisals of coping ability and agency. Post-conflict sNGF recovery related to lower anticipatory stress appraisals, and to higher agency and well-being. These results support the idea that dynamic sNGF responses are adaptive. Implications for the potential role of the neurotrophic system in stress resilience are discussed.
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U2 - 10.1016/j.physbeh.2014.02.034
DO - 10.1016/j.physbeh.2014.02.034
M3 - Article
C2 - 24582676
AN - SCOPUS:84896030843
SN - 0031-9384
VL - 129
SP - 130
EP - 134
JO - Physiology and Behavior
JF - Physiology and Behavior
ER -