Two types of biodegradable block polyurethanes based on polycaprolactone (PCL) and poly(ethylene glycol) (PEG) were prepared by controlling the regularity of block arrangements, that is, alternating block polyurethanes PUCL-. alt-PEG. Traditional random block polyurethanes PUCL-. ran-PEG were also prepared for comparison. Nerve repair scaffolds were prepared from these block polyurethanes. The nerve repair scaffolds were tested in a Sprague-Dawley rat peripheral nerve defect model. The nerve regeneration was evaluated by sciatic function index analysis and histological analyses. Results revealed that polyurethane nerve-guided scaffolds exhibited much greater regeneration capabilities than PCL. Particularly, PUCL-. alt-PEG exhibited better nerve regeneration than the autograft. These studies warrant further studies toward optimization of the block polyurethane nerve-guided scaffolds for peripheral nerve regeneration.
|Title of host publication
|Advances in Polyurethane Biomaterials
|Number of pages
|Published - Feb 2 2016
All Science Journal Classification (ASJC) codes
- General Medicine
- General Health Professions