TY - GEN
T1 - Scaling analysis of a universal electrode for molecular biosensors
AU - Sin, Mandy L.Y.
AU - Constantino, Victor U.
AU - Gau, Vincent
AU - Haake, David A.
AU - Wong, Pak Kin
PY - 2008
Y1 - 2008
N2 - Nanoscale and molecular manipulation techniques, such as concentration, are crucial for the success of an automated point-of-care diagnostic system. Here, we report the development of an electrokinetic concentrator for integrated bioanalytical systems. By combining different electrokinetic forces, the concentrator is capable of concentrating nanoscale particles in less than 1 min and increasing the concentration by 2 orders of magnitude. The concentrator used a universal electrode design developed for a versatile electrochemical sensor platform. We performed a scaling analysis to generalize and optimize the design of the universal electrode. The data collapse analysis showed that the concentration process follows a universal kinetics, and the time scaling factor (7) scales with the effective electric field (E) as T ∼ e 0.48±.05 while the intensity scaling factor (I) increases with the effective electric field (E) as I ∼E0.93±0.1.2.
AB - Nanoscale and molecular manipulation techniques, such as concentration, are crucial for the success of an automated point-of-care diagnostic system. Here, we report the development of an electrokinetic concentrator for integrated bioanalytical systems. By combining different electrokinetic forces, the concentrator is capable of concentrating nanoscale particles in less than 1 min and increasing the concentration by 2 orders of magnitude. The concentrator used a universal electrode design developed for a versatile electrochemical sensor platform. We performed a scaling analysis to generalize and optimize the design of the universal electrode. The data collapse analysis showed that the concentration process follows a universal kinetics, and the time scaling factor (7) scales with the effective electric field (E) as T ∼ e 0.48±.05 while the intensity scaling factor (I) increases with the effective electric field (E) as I ∼E0.93±0.1.2.
UR - http://www.scopus.com/inward/record.url?scp=50249116254&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=50249116254&partnerID=8YFLogxK
U2 - 10.1109/NEMS.2008.4484521
DO - 10.1109/NEMS.2008.4484521
M3 - Conference contribution
AN - SCOPUS:50249116254
SN - 9781424419081
T3 - 3rd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS
SP - 1151
EP - 1155
BT - 3rd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2008
T2 - 3rd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2008
Y2 - 6 January 2008 through 9 January 2008
ER -