'Screw-cap' clamp loader proteins that thread

Zhihao Zhuang, Michelle Marie Spiering, Anthony J. Berdis, Michael A. Trakselis, Stephen Benkovic

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations


Structures of the clamp loader-clamp complex reveal that nature uses machined parts in the form of a spiral scaffold (the clamp loader) to thread a circlet (the clamp) on a helix of DNA. The scaffold is then replaced by an interpretive copying machine, the polymerase, to eventually generate the replisome for DNA replication.

Original languageEnglish (US)
Pages (from-to)580-581
Number of pages2
JournalNature Structural and Molecular Biology
Issue number7
StatePublished - Jul 2004

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology


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