SDCBP promotes pancreatic cancer progression by preventing YAP1 from β-TrCP-mediated proteasomal degradation

Keyphrases

• Yes-associated Protein 1 (YAP1) 100%
• Proteasomal Degradation 100%
• Pancreatic Cancer Progression 100%
• Syndecan Binding Protein 100%
• Pancreatic Ductal Adenocarcinoma 63%
• Metastasis 18%
• Tumor Progression 18%
• Therapeutic Strategies 18%
• Protein Clustering 18%
• Zinc Pyrithione 18%
• Tumor 9%
• Phosphorylation 9%
• Protein Expression 9%
• Immunostaining 9%
• Co-immunoprecipitation (co-IP) 9%
• Cell Apoptosis 9%
• Median Overall Survival 9%
• Colony Formation Assay 9%
• Recurrence-free Survival 9%
• Degradation Test 9%
• Ethynyl 9%
• Invadopodia 9%
• Pdx1-Cre 9%
• Limited Treatment Options 9%
• Apoptosis Assay 9%
• Real-time Cell Analysis 9%
• KPC Mice 9%
• KPC Mouse Model 9%
• Automated Cell Tracking 9%
• Human Organoid Models 9%
• Gelatin Degradation 9%
• Promising Therapeutics 9%
• KRAS G12D 9%
• Targetable 9%
• Pull-down 9%
• 2′-deoxyuridine 9%
• Ubiquitination Degradation 9%

Biochemistry, Genetics and Molecular Biology

• Binding Protein 100%
• YAP1 100%
• Syndecan 100%
• Tumor Progression 18%
• Mouse Model 18%
• Protein Expression 9%
• Proteasome 9%
• In Vivo Study 9%
• Survival Rate 9%
• Colony Formation 9%
• Ubiquitination 9%
• Overall Survival 9%
• Immunostaining 9%
• Recurrence Free Survival 9%
• Apoptosis Assay 9%
• Deoxyuridine 9%
• Invadopodia 9%
• phosphorylation 9%

Immunology and Microbiology

• Protein Binding 100%
• Mouse Model 18%
• Proteasome 9%
• Survival Rate 9%
• Immunostaining 9%
• Colony Formation 9%
• Overall Survival 9%
• Protein Expression 9%
• Ubiquitination 9%
• Recurrence Free Survival 9%
• Organoid 9%
• Programmed Cell Death 9%
• In Vitro 9%
• phosphorylation 9%