Abstract
HBV replicates its DNA genome, a partially double-stranded, relaxed circular DNA, via reverse transcription of an RNA intermediate called pre-genomic RNA by its reverse transcriptase. A major characteristic of HBV replication is the selective envelopment and secretion of relaxed circular DNA-containing mature capsids and empty capsids with no DNA or RNA, but not those containing pre-genomic RNA or the single-stranded DNA replication intermediate. In this review, the potential mechanisms of HBV virion morphogenesis will be discussed, with a focus on key determinants of both the capsid and envelope proteins for the selective secretion of complete and empty virions.
Original language | English (US) |
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Pages (from-to) | 95-105 |
Number of pages | 11 |
Journal | Future Virology |
Volume | 14 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2019 |
All Science Journal Classification (ASJC) codes
- Virology