Secretory-IgA binding to intestinal microbiota attenuates inflammatory reactions as the intestinal barrier of preterm infants matures

Sarah M. Mahdally, Mariana Izquierdo, Rose M. Viscardi, Laurence S. Magder, Helena M. Crowley, Andrea C. Bafford, Cinthia B. Drachenberg, Mauricio J. Farfan, Alessio Fasano, Marcelo B. Sztein, Rosangela Salerno-Goncalves

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Previous work has shown that Secretory-IgA (SIgA) binding to the intestinal microbiota is variable and may regulate host inflammatory bowel responses. Nevertheless, the impact of the SIgA functional binding to the microbiota remains largely unknown in preterm infants whose immature epithelial barriers make them particularly susceptible to inflammation. Here, we investigated SIgA binding to intestinal microbiota isolated from stools of preterm infants <33 weeks gestation with various levels of intestinal permeability. We found that SIgA binding to intestinal microbiota attenuates inflammatory reactions in preterm infants. We also observed a significant correlation between SIgA affinity to the microbiota and the infant's intestinal barrier maturation. Still, SIgA affinity was not associated with developing host defenses, such as the production of mucus and inflammatory calprotectin protein, but it depended on the microbiota shifts as the intestinal barrier matures. In conclusion, we reported an association between the SIgA functional binding to the microbiota and the maturity of the preterm infant's intestinal barrier, indicating that the pattern of SIgA coating is altered as the intestinal barrier matures.

Original languageEnglish (US)
Pages (from-to)339-356
Number of pages18
JournalClinical and Experimental Immunology
Volume213
Issue number3
DOIs
StatePublished - Sep 2023

All Science Journal Classification (ASJC) codes

  • General Medicine

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