Secretory Phospholipase A₂ Enzymes in Acute Lung Injury

The secretory phospholipase A₂ (sPLA₂) group of secreted enzymes hydrolyze phospholipids and lead to the production of multiple biologically active lipid mediators. sPLA₂s and their products (e.g., eicosanoids) play a significant role in the pathophysiology of various inflammatory diseases, including life-threatening lung disorders such as acute lung injury (ALI) and the Acute Respiratory Distress Syndrome (ARDS). The ALI/ARDS spectrum of severe inflammatory conditions is caused by direct (such as bacterial or viral pneumonia) or indirect insults (sepsis) that are associated with high morbidity and mortality. Several sPLA₂ isoforms are upregulated in patients with ARDS as well as in multiple ALI preclinical models, and individual sPLA₂s exert unique roles in regulating ALI pathophysiology. This brief review will summarize the contributions of specific sPLA₂ isoforms as markers and mediators in ALI, supporting a potential therapeutic role for targeting them in ARDS.