Seeing eye to eye with threat: Atypical Threat Bias in Children with 22q11.2 Deletion Syndrome

Abbie M. Popa, Joshua R. Cruz, Ling M. Wong, Danielle J. Harvey, Kathleen Angkustsiri, Ingrid N. Leckliter, Koraly Perez-Edgar, Tony J. Simon

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Individuals with 22q11.2 deletion syndrome (22q11DS) show high rates of anxiety associated with their increased risk of developing schizophrenia. Biased attention is associated with anxiety and is important to investigate in those with 22q11DS given this association. We analyzed attention bias to emotional faces in 7- to 17-year olds with 22q11DS and typically developing controls (TD) using a dot probe threat bias paradigm. We measured response time, eye tracking, and pupilometry. Those with 22q11DS showed no significant changes in early versus late trials, whereas those who were TD showed differing patterns in both gaze and pupilometry over time. The patterns in those who are TD may indicate adaptation that is lacking or slower in individuals with 22q11DS.

Original languageEnglish (US)
Pages (from-to)549-567
Number of pages19
JournalAmerican Journal on Intellectual and Developmental Disabilities
Issue number6
StatePublished - 2019

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Neuropsychology and Physiological Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Psychiatry and Mental health


Dive into the research topics of 'Seeing eye to eye with threat: Atypical Threat Bias in Children with 22q11.2 Deletion Syndrome'. Together they form a unique fingerprint.

Cite this