TY - JOUR
T1 - Seeing eye to eye with threat
T2 - Atypical Threat Bias in Children with 22q11.2 Deletion Syndrome
AU - Popa, Abbie M.
AU - Cruz, Joshua R.
AU - Wong, Ling M.
AU - Harvey, Danielle J.
AU - Angkustsiri, Kathleen
AU - Leckliter, Ingrid N.
AU - Perez-Edgar, Koraly
AU - Simon, Tony J.
N1 - Funding Information:
This work was supported by NIH R01 HD042974 and U54 HD079125. AMP was supported in part by NIH training grant T32 MH82174 funded by the Jointly Sponsored Ruth L. Kirschstein NRSA Institutional Predoctoral Training Program in the Neurosciences.
Publisher Copyright:
© AAIDD
PY - 2019
Y1 - 2019
N2 - Individuals with 22q11.2 deletion syndrome (22q11DS) show high rates of anxiety associated with their increased risk of developing schizophrenia. Biased attention is associated with anxiety and is important to investigate in those with 22q11DS given this association. We analyzed attention bias to emotional faces in 7- to 17-year olds with 22q11DS and typically developing controls (TD) using a dot probe threat bias paradigm. We measured response time, eye tracking, and pupilometry. Those with 22q11DS showed no significant changes in early versus late trials, whereas those who were TD showed differing patterns in both gaze and pupilometry over time. The patterns in those who are TD may indicate adaptation that is lacking or slower in individuals with 22q11DS.
AB - Individuals with 22q11.2 deletion syndrome (22q11DS) show high rates of anxiety associated with their increased risk of developing schizophrenia. Biased attention is associated with anxiety and is important to investigate in those with 22q11DS given this association. We analyzed attention bias to emotional faces in 7- to 17-year olds with 22q11DS and typically developing controls (TD) using a dot probe threat bias paradigm. We measured response time, eye tracking, and pupilometry. Those with 22q11DS showed no significant changes in early versus late trials, whereas those who were TD showed differing patterns in both gaze and pupilometry over time. The patterns in those who are TD may indicate adaptation that is lacking or slower in individuals with 22q11DS.
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U2 - 10.1352/1944-7558-124.6.549
DO - 10.1352/1944-7558-124.6.549
M3 - Article
C2 - 31756146
AN - SCOPUS:85075479596
SN - 1944-7515
VL - 124
SP - 549
EP - 567
JO - American Journal on Intellectual and Developmental Disabilities
JF - American Journal on Intellectual and Developmental Disabilities
IS - 6
ER -
