Selective IgM deficiency in CD30+ cutaneous lymphoproliferative disorder

Surbhi Saini, Andrew J. Dettore, Kanta J. Bhambhani, Steven Buck, Janet Poulik, Süreyya Savaşan

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Primary cutaneous anaplastic large cell lymphoma with local lymph node involvement was diagnosed in a 13-year-old boy with an ulcerative facial lesion and a history of skin lesions of lymphomatoid papulosis. The tumor regressed with chemotherapy. He continued to develop recurrent self-limited lesions of lymphomatoid papulosis , with a halo surrounding these lesions during the healing phase. He developed selective immunoglobulin M deficiency with decline in levels even 4 years after the chemotherapy with no recurrent infections noted and adequate IgG response to immunizations. Both peripheral blood IgM and memory B cells were low, suggesting a possible cause-effect relationship between selective immunoglobulin M deficiency and chronic CD30 cutaneous lymphoproliferative disorders.

Original languageEnglish (US)
Pages (from-to)e156-e159
JournalJournal of pediatric hematology/oncology
Issue number4
StatePublished - May 2011

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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