Selective neuronal vulnerability to hypoxia in vitro

Peter G. Aitken; Steven Schiff

doi:10.1016/0304-3940(86)90215-6

Selective neuronal vulnerability to hypoxia in vitro

Peter G. Aitken, Steven Schiff

Research output: Contribution to journal › Article › peer-review

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Abstract

Hippocampal slices were subjected to a sequence of hypoxic periods of progressively increasing duration. In all slices, synaptic transmission returned during reoxygenation in the fascia dentata, but not in CA1. Thus, the relative vulnerability of CA1 and the fascia dentata to ischemia in situ can be replicated by a purely hypoxic insult in vitro.

Original language	English (US)
Pages (from-to)	92-96
Number of pages	5
Journal	Neuroscience letters
Volume	67
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(86)90215-6
State	Published - Jun 6 1986

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1016/0304-3940(86)90215-6

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title = "Selective neuronal vulnerability to hypoxia in vitro",

abstract = "Hippocampal slices were subjected to a sequence of hypoxic periods of progressively increasing duration. In all slices, synaptic transmission returned during reoxygenation in the fascia dentata, but not in CA1. Thus, the relative vulnerability of CA1 and the fascia dentata to ischemia in situ can be replicated by a purely hypoxic insult in vitro.",

author = "Aitken, {Peter G.} and Steven Schiff",

note = "Funding Information: We thank George G. Somjen for his advice. This work was supported by the Research Foundation of the American Association of Neurological Surgery and USPHS Grants NS 18670 and NS 17771.",

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AU - Schiff, Steven

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PY - 1986/6/6

Y1 - 1986/6/6

N2 - Hippocampal slices were subjected to a sequence of hypoxic periods of progressively increasing duration. In all slices, synaptic transmission returned during reoxygenation in the fascia dentata, but not in CA1. Thus, the relative vulnerability of CA1 and the fascia dentata to ischemia in situ can be replicated by a purely hypoxic insult in vitro.

AB - Hippocampal slices were subjected to a sequence of hypoxic periods of progressively increasing duration. In all slices, synaptic transmission returned during reoxygenation in the fascia dentata, but not in CA1. Thus, the relative vulnerability of CA1 and the fascia dentata to ischemia in situ can be replicated by a purely hypoxic insult in vitro.

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Selective neuronal vulnerability to hypoxia in vitro

Abstract

All Science Journal Classification (ASJC) codes

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