Selective Sweeps

Z. A. Szpiech; R. D. Hernandez

doi:10.1016/B978-0-12-800049-6.00039-1

Selective Sweeps

Z. A. Szpiech, R. D. Hernandez

Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

The model of a de novo adaptive mutation arising in a population and rising to high frequency is referred to as a selective sweep and has been the subject of much theoretical study. Here we describe the basic model, the expected genetic patterns that result from such a process, and two major classes of statistics designed to infer genomic locations that have recently experienced a selective sweep (those based on the site frequency spectrum and those based on haplotype patterns). We conclude by discussing caveats to the model and possible alternatives that are gaining traction in the field.

Original language	English (US)
Title of host publication	Encyclopedia of Evolutionary Biology
Publisher	Elsevier Inc.
Pages	23-32
Number of pages	10
ISBN (Electronic)	9780128004265
ISBN (Print)	9780128000496
DOIs	https://doi.org/10.1016/B978-0-12-800049-6.00039-1
State	Published - Apr 14 2016

All Science Journal Classification (ASJC) codes

General Agricultural and Biological Sciences
General Biochemistry, Genetics and Molecular Biology

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10.1016/B978-0-12-800049-6.00039-1

Cite this

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AB - The model of a de novo adaptive mutation arising in a population and rising to high frequency is referred to as a selective sweep and has been the subject of much theoretical study. Here we describe the basic model, the expected genetic patterns that result from such a process, and two major classes of statistics designed to infer genomic locations that have recently experienced a selective sweep (those based on the site frequency spectrum and those based on haplotype patterns). We conclude by discussing caveats to the model and possible alternatives that are gaining traction in the field.

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ER -

Selective Sweeps

Abstract

All Science Journal Classification (ASJC) codes

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