Selenium and selenoproteins in prostanoid metabolism and immunity

Fenghua Qian, Sougat Misra, K. Sandeep Prabhu

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations


Selenium (Se) is an essential trace element that functions in the form of the 21st amino acid, selenocysteine (Sec) in a defined set of proteins. Se deficiency is associated with pathological conditions in humans and animals, where incorporation of Sec into selenoproteins is reduced along with their expression and catalytic activity. Supplementation of Se-deficient population with Se has shown health benefits suggesting the importance of Se in physiology. An interesting paradigm to explain, in part, the health benefits of Se stems from the observations that selenoprotein-dependent modulation of inflammation and efficient resolution of inflammation relies on mechanisms involving a group of bioactive lipid mediators, prostanoids, which orchestrate a concerted action toward maintenance and restoration of homeostatic immune responses. Such an effect involves the interaction of various immune cells with these lipid mediators where cellular redox gatekeeper functions of selenoproteins further aid in not only dampening inflammation, but also initiating an effective and active resolution process. Here we have summarized the current literature on the multifaceted roles of Se/selenoproteins in the regulation of these bioactive lipid mediators and their immunomodulatory effects.

Original languageEnglish (US)
Pages (from-to)484-516
Number of pages33
JournalCritical Reviews in Biochemistry and Molecular Biology
Issue number6
StatePublished - Nov 2 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology


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