TY - JOUR
T1 - Seleno-Metabolites and Their Precursors
T2 - A New Dawn for Several Illnesses?
AU - Morán-Serradilla, Cristina
AU - Angulo-Elizari, Eduardo
AU - Henriquez-Figuereo, Andreina
AU - Sanmartín, Carmen
AU - Sharma, Arun K.
AU - Plano, Daniel
N1 - Funding Information:
This work was funded by Plan de Investigación de la Universidad de Navarra, PIUNA (2018-19). Cristina Morán-Serradilla acknowledges the support of Gobierno de Navarra for a Ph.D. fellowship. Andreina Henriquez-Figuereo acknowledges the Instituto de Salud Tropical de la Universidad de Navarra (ISTUN) for a Ph.D. fellowship.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/9
Y1 - 2022/9
N2 - Selenium (Se) is an essential element for human health as it is involved in different physiological functions. Moreover, a great number of Se compounds can be considered potential agents in the prevention and treatment of some diseases. It is widely recognized that Se activity is related to multiple factors, such as its chemical form, dose, and its metabolism. The understanding of its complex biochemistry is necessary as it has been demonstrated that the metabolites of the Se molecules used to be the ones that exert the biological activity. Therefore, the aim of this review is to summarize the recent information about its most remarkable metabolites of acknowledged biological effects: hydrogen selenide (HSe−/H2Se) and methylselenol (CH3SeH). In addition, special attention is paid to the main seleno-containing precursors of these derivatives and their role in different pathologies.
AB - Selenium (Se) is an essential element for human health as it is involved in different physiological functions. Moreover, a great number of Se compounds can be considered potential agents in the prevention and treatment of some diseases. It is widely recognized that Se activity is related to multiple factors, such as its chemical form, dose, and its metabolism. The understanding of its complex biochemistry is necessary as it has been demonstrated that the metabolites of the Se molecules used to be the ones that exert the biological activity. Therefore, the aim of this review is to summarize the recent information about its most remarkable metabolites of acknowledged biological effects: hydrogen selenide (HSe−/H2Se) and methylselenol (CH3SeH). In addition, special attention is paid to the main seleno-containing precursors of these derivatives and their role in different pathologies.
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U2 - 10.3390/metabo12090874
DO - 10.3390/metabo12090874
M3 - Review article
C2 - 36144278
AN - SCOPUS:85138639744
SN - 2218-1989
VL - 12
JO - Metabolites
JF - Metabolites
IS - 9
M1 - 874
ER -