Self-reported sleep efficiency and duration are associated with bioenergetic function in peripheral blood mononuclear cells (PBMCs) of adults

H. Matthew Lehrer; Lauren E. Chu; Martica H. Hall; Kyle W. Murdock

doi:10.1016/j.mito.2021.11.005

Self-reported sleep efficiency and duration are associated with bioenergetic function in peripheral blood mononuclear cells (PBMCs) of adults

H. Matthew Lehrer, Lauren E. Chu, Martica H. Hall, Kyle W. Murdock

Biobehavioral Health

Research output: Contribution to journal › Article › peer-review

Abstract

Poor sleep may impair systemic mitochondrial bioenergetics, but this relationship has not been examined in humans. This study examined associations of self-reported sleep with peripheral blood mononuclear cell (PBMC) bioenergetics in adults. Forty-three participants completed the Pittsburgh Sleep Quality Index from which sleep indices were calculated. PBMCs were analyzed for bioenergetics using extracellular flux analysis. Sleep efficiency was positively correlated with maximal respiration and spare capacity. Lower sleep efficiency and longer sleep duration were associated with lower Bioenergetic Health Index in age-, sex-, and body mass index-adjusted models. Findings indicate that sleep is related to systemic bioenergetic function in humans.

Original language	English (US)
Pages (from-to)	122-127
Number of pages	6
Journal	Mitochondrion
Volume	62
DOIs	https://doi.org/10.1016/j.mito.2021.11.005
State	Published - Jan 2022

All Science Journal Classification (ASJC) codes

Molecular Medicine
Molecular Biology
Cell Biology

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title = "Self-reported sleep efficiency and duration are associated with bioenergetic function in peripheral blood mononuclear cells (PBMCs) of adults",

abstract = "Poor sleep may impair systemic mitochondrial bioenergetics, but this relationship has not been examined in humans. This study examined associations of self-reported sleep with peripheral blood mononuclear cell (PBMC) bioenergetics in adults. Forty-three participants completed the Pittsburgh Sleep Quality Index from which sleep indices were calculated. PBMCs were analyzed for bioenergetics using extracellular flux analysis. Sleep efficiency was positively correlated with maximal respiration and spare capacity. Lower sleep efficiency and longer sleep duration were associated with lower Bioenergetic Health Index in age-, sex-, and body mass index-adjusted models. Findings indicate that sleep is related to systemic bioenergetic function in humans.",

author = "Lehrer, {H. Matthew} and Chu, {Lauren E.} and Hall, {Martica H.} and Murdock, {Kyle W.}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V. and Mitochondria Research Society",

year = "2022",

month = jan,

doi = "10.1016/j.mito.2021.11.005",

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AU - Lehrer, H. Matthew

AU - Chu, Lauren E.

AU - Hall, Martica H.

AU - Murdock, Kyle W.

PY - 2022/1

Y1 - 2022/1

N2 - Poor sleep may impair systemic mitochondrial bioenergetics, but this relationship has not been examined in humans. This study examined associations of self-reported sleep with peripheral blood mononuclear cell (PBMC) bioenergetics in adults. Forty-three participants completed the Pittsburgh Sleep Quality Index from which sleep indices were calculated. PBMCs were analyzed for bioenergetics using extracellular flux analysis. Sleep efficiency was positively correlated with maximal respiration and spare capacity. Lower sleep efficiency and longer sleep duration were associated with lower Bioenergetic Health Index in age-, sex-, and body mass index-adjusted models. Findings indicate that sleep is related to systemic bioenergetic function in humans.

AB - Poor sleep may impair systemic mitochondrial bioenergetics, but this relationship has not been examined in humans. This study examined associations of self-reported sleep with peripheral blood mononuclear cell (PBMC) bioenergetics in adults. Forty-three participants completed the Pittsburgh Sleep Quality Index from which sleep indices were calculated. PBMCs were analyzed for bioenergetics using extracellular flux analysis. Sleep efficiency was positively correlated with maximal respiration and spare capacity. Lower sleep efficiency and longer sleep duration were associated with lower Bioenergetic Health Index in age-, sex-, and body mass index-adjusted models. Findings indicate that sleep is related to systemic bioenergetic function in humans.

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JO - Mitochondrion

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ER -

Self-reported sleep efficiency and duration are associated with bioenergetic function in peripheral blood mononuclear cells (PBMCs) of adults

Abstract

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