TY - JOUR
T1 - Semantic association investigated with functional MRI and independent component analysis
AU - Kim, Kwang Ki
AU - Karunanayaka, Prasanna
AU - Privitera, Michael D.
AU - Holland, Scott K.
AU - Szaflarski, Jerzy P.
N1 - Funding Information:
This study was presented in part at the 62nd Annual Meeting of the American Academy of Neurology, Toronto, ON, Canada. Dr. Kim is supported in part by a fellowship from Dongguk University and in part by funds from the Charles and Pamela Shor Foundation. Initial support for this study was provided by The Neuroscience Institute in Cincinnati (J.P.S.). Further support also includes NIH Grants R01 HD38578 (SKH) and R01 NS048281 (J.P.S.). Dr. Szaflarski is currently supported by NIH K23 NS052468.
PY - 2011/4
Y1 - 2011/4
N2 - Semantic association, an essential element of human language, enables discourse and inference. Neuroimaging studies have revealed localization and lateralization of semantic circuitry, making substantial contributions to cognitive neuroscience. However, because of methodological limitations, these investigations have only identified individual functional components rather than capturing the behavior of the entire network. To overcome these limitations, we have implemented group independent component analysis (ICA) to investigate the cognitive modules used by healthy adults performing the fMRI semantic decision task. When compared with the results of a standard general linear modeling (GLM) analysis, ICA detected several additional brain regions subserving semantic decision. Eight task-related group ICA maps were identified, including left inferior frontal gyrus (BA44/45), middle posterior temporal gyrus (BA39/22), angular gyrus/inferior parietal lobule (BA39/40), posterior cingulate (BA30), bilateral lingual gyrus (BA18/23), inferior frontal gyrus (L > R, BA47), hippocampus with parahippocampal gyrus (L > R, BA35/36), and anterior cingulate (BA32/24). Although most of the components were represented bilaterally, we found a single, highly left-lateralized component that included the inferior frontal gyrus and the medial and superior temporal gyri, the angular and supramarginal gyri, and the inferior parietal cortex. The presence of these spatially independent ICA components implies functional connectivity and can be equated with their modularity. These results are analyzed and presented in the framework of a biologically plausible theoretical model in preparation for similar analyses in patients with right- or left-hemispheric epilepsies.
AB - Semantic association, an essential element of human language, enables discourse and inference. Neuroimaging studies have revealed localization and lateralization of semantic circuitry, making substantial contributions to cognitive neuroscience. However, because of methodological limitations, these investigations have only identified individual functional components rather than capturing the behavior of the entire network. To overcome these limitations, we have implemented group independent component analysis (ICA) to investigate the cognitive modules used by healthy adults performing the fMRI semantic decision task. When compared with the results of a standard general linear modeling (GLM) analysis, ICA detected several additional brain regions subserving semantic decision. Eight task-related group ICA maps were identified, including left inferior frontal gyrus (BA44/45), middle posterior temporal gyrus (BA39/22), angular gyrus/inferior parietal lobule (BA39/40), posterior cingulate (BA30), bilateral lingual gyrus (BA18/23), inferior frontal gyrus (L > R, BA47), hippocampus with parahippocampal gyrus (L > R, BA35/36), and anterior cingulate (BA32/24). Although most of the components were represented bilaterally, we found a single, highly left-lateralized component that included the inferior frontal gyrus and the medial and superior temporal gyri, the angular and supramarginal gyri, and the inferior parietal cortex. The presence of these spatially independent ICA components implies functional connectivity and can be equated with their modularity. These results are analyzed and presented in the framework of a biologically plausible theoretical model in preparation for similar analyses in patients with right- or left-hemispheric epilepsies.
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U2 - 10.1016/j.yebeh.2010.11.010
DO - 10.1016/j.yebeh.2010.11.010
M3 - Article
C2 - 21296027
AN - SCOPUS:79954579928
SN - 1525-5050
VL - 20
SP - 613
EP - 622
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
IS - 4
ER -