Semi-automated quantification of the regional left ventricular response to dobutamine stress by Tissue Doppler echocardiography

William E. Katz, Sunil Mankad, William A. Mandarino, John Gorcsan

Research output: Contribution to journalArticlepeer-review


Tissue Doppler imaging (TDI) may quantify regional left ventricular (LV) function, but extraction of color-coded velocity data has previously required off-line visual comparison to a color velocity map. The objective was to assess the regional LV response to dobutamine stress using a new semi-automated TDI data analysis system. Eight patients, aged 60±12 yrs, with normal posterior wall function at rest and peak stress were studied. Color TDI M-modes (Toshiba 380A) were obtained at rest, at low dose (5 μg/kg/min) and at peak dobutamine stress (45±8 μg/kg/min). Endocardial velocity and time-velocity gradients (TVG) were plotted from a digital velocity matrix (examples shown). Baseline data were: peak systolic velocity 45 ± 22 mm/sec, systolic TVG 3.1 ± 0.9 sec-1, peak diastolic velocity 68 ± 41 mm/sec, and diastolic TVG 3.8 ± 1.5 sec-1. Peak systolic and diastolic velocities increased with low dose dobutamine to 66 ± 32*, and 74 ± 31* mm/sec, respectively (*p<0.05 vs. baseline). Further changes occurred at peak stress: peak systolic velocity increased to 106 ± 19 mm/sec*#, systolic TVG increased to 6.8 ± 2.7# sec-1, peak diastolic velocity increased to 89 ± 36 mm/sec*# and diastolic TVG increased to 6.4 ± 1.4 sec-1* (* p<0.001 vs. baseline, # p<0.05 vs. low dose). Conclusion: Semi-automated TDI analysis has potential to rapidly quantify regional LV function during dobutamine stress echocardiography.

Original languageEnglish (US)
Pages (from-to)433
Number of pages1
JournalJournal of the American Society of Echocardiography
Issue number4
StatePublished - 1997

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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