Sequence analysis of the Staphylococcus aureus srrAB loci reveals that truncation of srrA affects growth and virulence factor expression

Alexa A. Pragman; Lisa Herron-Olson; Laura C. Case; Sara M. Vetter; Evan E. Henke; Vivek Kapur; Patrick M. Schlievert

doi:10.1128/JB.00547-07

Sequence analysis of the Staphylococcus aureus srrAB loci reveals that truncation of srrA affects growth and virulence factor expression

Alexa A. Pragman, Lisa Herron-Olson, Laura C. Case, Sara M. Vetter, Evan E. Henke, Vivek Kapur, Patrick M. Schlievert

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The SrrAB system regulates metabolism and virulence factors in Staphylococcus aureus. We sequenced the srrAB loci of 21 isolates and performed a phylogenetic analysis. Vaginal and bovine isolates clustered together, while skin isolates were genetically diverse. Few nucleotide polymorphisms were observed, and most were synonymous. Two strains (N2 and N19) with N-terminal truncations in SrrA displayed defects in growth and abnormally upregulated virulence factor expression under low-oxygen conditions.

Original language	English (US)
Pages (from-to)	7515-7519
Number of pages	5
Journal	Journal of bacteriology
Volume	189
Issue number	20
DOIs	https://doi.org/10.1128/JB.00547-07
State	Published - Oct 2007

All Science Journal Classification (ASJC) codes

Microbiology
Molecular Biology

Access to Document

10.1128/JB.00547-07

Cite this

@article{b8973723001a4136833034b8d3793fb2,

title = "Sequence analysis of the Staphylococcus aureus srrAB loci reveals that truncation of srrA affects growth and virulence factor expression",

abstract = "The SrrAB system regulates metabolism and virulence factors in Staphylococcus aureus. We sequenced the srrAB loci of 21 isolates and performed a phylogenetic analysis. Vaginal and bovine isolates clustered together, while skin isolates were genetically diverse. Few nucleotide polymorphisms were observed, and most were synonymous. Two strains (N2 and N19) with N-terminal truncations in SrrA displayed defects in growth and abnormally upregulated virulence factor expression under low-oxygen conditions.",

author = "Pragman, {Alexa A.} and Lisa Herron-Olson and Case, {Laura C.} and Vetter, {Sara M.} and Henke, {Evan E.} and Vivek Kapur and Schlievert, {Patrick M.}",

year = "2007",

month = oct,

doi = "10.1128/JB.00547-07",

language = "English (US)",

volume = "189",

pages = "7515--7519",

journal = "Journal of bacteriology",

issn = "0021-9193",

publisher = "American Society for Microbiology",

number = "20",

}

TY - JOUR

T1 - Sequence analysis of the Staphylococcus aureus srrAB loci reveals that truncation of srrA affects growth and virulence factor expression

AU - Pragman, Alexa A.

AU - Herron-Olson, Lisa

AU - Case, Laura C.

AU - Vetter, Sara M.

AU - Henke, Evan E.

AU - Kapur, Vivek

AU - Schlievert, Patrick M.

PY - 2007/10

Y1 - 2007/10

N2 - The SrrAB system regulates metabolism and virulence factors in Staphylococcus aureus. We sequenced the srrAB loci of 21 isolates and performed a phylogenetic analysis. Vaginal and bovine isolates clustered together, while skin isolates were genetically diverse. Few nucleotide polymorphisms were observed, and most were synonymous. Two strains (N2 and N19) with N-terminal truncations in SrrA displayed defects in growth and abnormally upregulated virulence factor expression under low-oxygen conditions.

AB - The SrrAB system regulates metabolism and virulence factors in Staphylococcus aureus. We sequenced the srrAB loci of 21 isolates and performed a phylogenetic analysis. Vaginal and bovine isolates clustered together, while skin isolates were genetically diverse. Few nucleotide polymorphisms were observed, and most were synonymous. Two strains (N2 and N19) with N-terminal truncations in SrrA displayed defects in growth and abnormally upregulated virulence factor expression under low-oxygen conditions.

UR - http://www.scopus.com/inward/record.url?scp=35048853211&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35048853211&partnerID=8YFLogxK

U2 - 10.1128/JB.00547-07

DO - 10.1128/JB.00547-07

M3 - Article

C2 - 17693503

AN - SCOPUS:35048853211

SN - 0021-9193

VL - 189

SP - 7515

EP - 7519

JO - Journal of bacteriology

JF - Journal of bacteriology

IS - 20

ER -

Sequence analysis of the Staphylococcus aureus srrAB loci reveals that truncation of srrA affects growth and virulence factor expression

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this