Sequence analysis of the Staphylococcus aureus srrAB loci reveals that truncation of srrA affects growth and virulence factor expression

Alexa A. Pragman; Lisa Herron-Olson; Laura C. Case; Sara M. Vetter; Evan E. Henke; Vivek Kapur; Patrick M. Schlievert

doi:10.1128/JB.00547-07

Sequence analysis of the Staphylococcus aureus srrAB loci reveals that truncation of srrA affects growth and virulence factor expression

Alexa A. Pragman
, Lisa Herron-Olson
, Laura C. Case
, Sara M. Vetter
, Evan E. Henke
, Vivek Kapur
, Patrick M. Schlievert

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The SrrAB system regulates metabolism and virulence factors in Staphylococcus aureus. We sequenced the srrAB loci of 21 isolates and performed a phylogenetic analysis. Vaginal and bovine isolates clustered together, while skin isolates were genetically diverse. Few nucleotide polymorphisms were observed, and most were synonymous. Two strains (N2 and N19) with N-terminal truncations in SrrA displayed defects in growth and abnormally upregulated virulence factor expression under low-oxygen conditions.

Original language	English (US)
Pages (from-to)	7515-7519
Number of pages	5
Journal	Journal of bacteriology
Volume	189
Issue number	20
DOIs	https://doi.org/10.1128/JB.00547-07
State	Published - Oct 2007

All Science Journal Classification (ASJC) codes

Microbiology
Molecular Biology

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10.1128/JB.00547-07

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title = "Sequence analysis of the Staphylococcus aureus srrAB loci reveals that truncation of srrA affects growth and virulence factor expression",

abstract = "The SrrAB system regulates metabolism and virulence factors in Staphylococcus aureus. We sequenced the srrAB loci of 21 isolates and performed a phylogenetic analysis. Vaginal and bovine isolates clustered together, while skin isolates were genetically diverse. Few nucleotide polymorphisms were observed, and most were synonymous. Two strains (N2 and N19) with N-terminal truncations in SrrA displayed defects in growth and abnormally upregulated virulence factor expression under low-oxygen conditions.",

author = "Pragman, \{Alexa A.\} and Lisa Herron-Olson and Case, \{Laura C.\} and Vetter, \{Sara M.\} and Henke, \{Evan E.\} and Vivek Kapur and Schlievert, \{Patrick M.\}",

year = "2007",

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doi = "10.1128/JB.00547-07",

language = "English (US)",

volume = "189",

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AU - Pragman, Alexa A.

AU - Herron-Olson, Lisa

AU - Case, Laura C.

AU - Vetter, Sara M.

AU - Henke, Evan E.

AU - Kapur, Vivek

AU - Schlievert, Patrick M.

PY - 2007/10

Y1 - 2007/10

N2 - The SrrAB system regulates metabolism and virulence factors in Staphylococcus aureus. We sequenced the srrAB loci of 21 isolates and performed a phylogenetic analysis. Vaginal and bovine isolates clustered together, while skin isolates were genetically diverse. Few nucleotide polymorphisms were observed, and most were synonymous. Two strains (N2 and N19) with N-terminal truncations in SrrA displayed defects in growth and abnormally upregulated virulence factor expression under low-oxygen conditions.

AB - The SrrAB system regulates metabolism and virulence factors in Staphylococcus aureus. We sequenced the srrAB loci of 21 isolates and performed a phylogenetic analysis. Vaginal and bovine isolates clustered together, while skin isolates were genetically diverse. Few nucleotide polymorphisms were observed, and most were synonymous. Two strains (N2 and N19) with N-terminal truncations in SrrA displayed defects in growth and abnormally upregulated virulence factor expression under low-oxygen conditions.

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UR - https://www.scopus.com/pages/publications/35048853211#tab=citedBy

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AN - SCOPUS:35048853211

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JO - Journal of bacteriology

JF - Journal of bacteriology

IS - 20

ER -

Sequence analysis of the Staphylococcus aureus srrAB loci reveals that truncation of srrA affects growth and virulence factor expression

Abstract

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