@inproceedings{08b941a03937482e92c19ad8d0ec5154,
title = "Sequence-Specific Recognition of SARS COV-2 with Solid-State CRISPR-Cas12a-Assisted Nanopores (SCAN)",
abstract = "The current outbreak of the SARS-CoV-2 caused the COVID-19 disease to spread rapidly globally. Specific and sensitive detection of SARS-CoV-2 is needed to prevent the disease from spread. Here, we present a solid-state CRISPR-Cas12a-assisted nanopores (SCAN) system to detect SARS-CoV-2. We introduced a new scheme using current drops and dwell times of ssDNA reporter translocation events to estimate the cleavage activity. We validated this scheme by a statistical model approximating the reporter length distribution over the cleavage reaction. We believe that the SCAN would provide a sensitive and specific detection method for SARS-COV-2.",
author = "Reza Nouri and Yuqian Jiang and Zifan Tang and Lian, {Xiaojun Lance} and Weihua Guan",
note = "Publisher Copyright: {\textcopyright} 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.; 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 ; Conference date: 10-10-2021 Through 14-10-2021",
year = "2021",
language = "English (US)",
series = "MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "833--834",
booktitle = "MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
}