Serum adiponectin, leptin, C-peptide, homocysteine, and colorectal adenoma recurrence in the polyp prevention trial

Gerd Bobe, Gwen Murphy, Connie J. Rogers, Kenneth W. Hance, Paul S. Albert, Adeyinka O. Laiyemo, Leah B. Sansbury, Elaine Lanza, Arthur Schatzkin, Amanda J. Cross

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Background: Serum adiponectin, leptin, C-peptide, and homocysteine are indicators for obesity, hyperinsulinemia, and chronic inflammation, which have all been associated with colorectal cancer. Aims: To determine whether serum adiponectin, leptin, C-peptide, and homocysteine are associated with fat, fiber, fruit and vegetable, flavonol, or dry bean intake and colorectal adenoma recurrence. Methods: Using logistic regression, we estimated odds ratios (OR) and 95% confidence intervals (95% CI) for adenoma recurrence in 627 participants from the control arm of the Polyp Prevention Trial, a 4-year trial that examined the effectiveness of a low-fat, high-fiber, high-fruit and vegetable diet on adenoma recurrence. Results: Serum concentrations of C-peptide and homocysteine were inversely related to fiber, fruit and vegetable, and flavonol intake and positively related to percentage of calories from fat (all P trend ≤0.01). High homocysteine concentrations were associated with any (4th versus 1st quartile: OR, 2.26; 95% CI, 1.30-3.94) and more than one adenoma recurrence (OR, 2.11; 95% CI, 1.01-4.40). Individuals in the highest, versus lowest, tertile of serum leptin concentration had a decreased risk of advanced adenoma recurrence (OR, 0.22; 95% CI, 0.06-0.79). Conclusion: Our results suggest that serum homocysteine may serve as an indicator of dietary exposure, including a low-fat and high-fiber, high-fruit and vegetable, and high-flavonol diet, as well as colorectal adenoma recurrence. Impact: Discovering biomarkers that are both modifiable and can predict cancer risk is critical. We identified serum homocysteine as a novel indicator that is modified by diet and predicts risk of adenoma recurrence.

Original languageEnglish (US)
Pages (from-to)1441-1452
Number of pages12
JournalCancer Epidemiology Biomarkers and Prevention
Issue number6
StatePublished - Jun 2010

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology


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