Serum HBV RNA composition dynamics as a marker for intrahepatic HBV cccDNA turnover

Xupeng Hong; Jianming Hu

doi:10.1002/jmv.25925

Serum HBV RNA composition dynamics as a marker for intrahepatic HBV cccDNA turnover

Xupeng Hong, Jianming Hu

Research output: Contribution to journal › Comment/debate › peer-review

5 Scopus citations

Abstract

Current therapies can suppress the replication of hepatitis B virus (HBV) but cannot clear chronic HBV infection, which afflicts hundreds of millions worldwide. HBV persistence is sustained by the viral covalently closed circular DNA (cccDNA), an episome in the nucleus of infected hepatocytes. cccDNA is refractory to current therapies and its clearance is the holy grail for HBV cure. However, it has been difficult to monitor the fate of cccDNA in the liver directly. The current study takes a novel approach to this critical issue by monitoring the dynamic change in the genetic composition of the serum HBV RNA, which appears to reflect the dynamics of intrahepatic cccDNA turnover.

Original language	English (US)
Pages (from-to)	935-937
Number of pages	3
Journal	Journal of Medical Virology
Volume	92
Issue number	8
DOIs	https://doi.org/10.1002/jmv.25925
State	Published - Aug 1 2020

All Science Journal Classification (ASJC) codes

Virology
Infectious Diseases

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jmv.25925

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title = "Serum HBV RNA composition dynamics as a marker for intrahepatic HBV cccDNA turnover",

abstract = "Current therapies can suppress the replication of hepatitis B virus (HBV) but cannot clear chronic HBV infection, which afflicts hundreds of millions worldwide. HBV persistence is sustained by the viral covalently closed circular DNA (cccDNA), an episome in the nucleus of infected hepatocytes. cccDNA is refractory to current therapies and its clearance is the holy grail for HBV cure. However, it has been difficult to monitor the fate of cccDNA in the liver directly. The current study takes a novel approach to this critical issue by monitoring the dynamic change in the genetic composition of the serum HBV RNA, which appears to reflect the dynamics of intrahepatic cccDNA turnover.",

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AU - Hu, Jianming

PY - 2020/8/1

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N2 - Current therapies can suppress the replication of hepatitis B virus (HBV) but cannot clear chronic HBV infection, which afflicts hundreds of millions worldwide. HBV persistence is sustained by the viral covalently closed circular DNA (cccDNA), an episome in the nucleus of infected hepatocytes. cccDNA is refractory to current therapies and its clearance is the holy grail for HBV cure. However, it has been difficult to monitor the fate of cccDNA in the liver directly. The current study takes a novel approach to this critical issue by monitoring the dynamic change in the genetic composition of the serum HBV RNA, which appears to reflect the dynamics of intrahepatic cccDNA turnover.

AB - Current therapies can suppress the replication of hepatitis B virus (HBV) but cannot clear chronic HBV infection, which afflicts hundreds of millions worldwide. HBV persistence is sustained by the viral covalently closed circular DNA (cccDNA), an episome in the nucleus of infected hepatocytes. cccDNA is refractory to current therapies and its clearance is the holy grail for HBV cure. However, it has been difficult to monitor the fate of cccDNA in the liver directly. The current study takes a novel approach to this critical issue by monitoring the dynamic change in the genetic composition of the serum HBV RNA, which appears to reflect the dynamics of intrahepatic cccDNA turnover.

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Serum HBV RNA composition dynamics as a marker for intrahepatic HBV cccDNA turnover

Abstract

All Science Journal Classification (ASJC) codes

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