Serum hormone levels in humans with low serum concentrations of 2,3,7,8-TCDD

Es Johnson, C. Shorter, Ll Bestervelt, Dg Patterson, Ll Needham, Wn Piper, G. Lucier, Cj Nolan

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


We measured current serum hormone and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) concentrations in 37 men who sprayed 2,4,5- trichlorophenoxyacetic acid (2,4,5-T) in the State of Victoria, Australia. TCDD levels were consistently significantly inversely related to prolactin levels in all analyses. In correlation analyses, TCDD levels were also inversely related to triiodothyronine (T3), thyroid-stimulating hormone (TSH), and testosterone levels, and positively associated with glucagon levels. The mean serum TCDD concentration in these sprayers was between 2.6 and 8.1 parts per trillion (ppt). Since such TCDD levels are commonly found in the general population in countries such as the US, the results could suggest that background levels of TCDD in the general population could have an effect on hormone levels. The findings are preliminary and need to be replicated in order to evaluate their full public health significance.

Original languageEnglish (US)
Pages (from-to)105-112
Number of pages8
JournalToxicology and Industrial Health
Issue number4
StatePublished - May 2001

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


Dive into the research topics of 'Serum hormone levels in humans with low serum concentrations of 2,3,7,8-TCDD'. Together they form a unique fingerprint.

Cite this