TY - JOUR
T1 - Serum soluble interleukin‐2 receptor levels in chronic progressive, stable and steroid‐treated multiple sclerosis
AU - Bansil, S.
AU - Troiano, R.
AU - Cook, S. D.
AU - Rohowsky‐Kochan, C.
PY - 1991/10
Y1 - 1991/10
N2 - ABSTRACT Serum levels of the soluble interleukin‐2 receptor (sIL‐2R), an indicator of T cell activation, were significantly elevated in chronic progressive MS (CPMS) patients, clinically stable MS patients and in patients with other neurological diseases (OND) as compared to healthy controls. Levels of sIL‐2R in steroid treated CPMS patients were markedly lower than in untreated CPMS patients and were comparable to healthy controls. Thus, systemic T cell activation occurs in MS during clinically stable and progressive disease stages and in other neurological disorders. The ability of oral corticosteroids to depress serum sIL‐2R levels in vivo may be one mechanism by which they exert their therapeutic effect. 1991 Blackwell Munksgaard
AB - ABSTRACT Serum levels of the soluble interleukin‐2 receptor (sIL‐2R), an indicator of T cell activation, were significantly elevated in chronic progressive MS (CPMS) patients, clinically stable MS patients and in patients with other neurological diseases (OND) as compared to healthy controls. Levels of sIL‐2R in steroid treated CPMS patients were markedly lower than in untreated CPMS patients and were comparable to healthy controls. Thus, systemic T cell activation occurs in MS during clinically stable and progressive disease stages and in other neurological disorders. The ability of oral corticosteroids to depress serum sIL‐2R levels in vivo may be one mechanism by which they exert their therapeutic effect. 1991 Blackwell Munksgaard
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U2 - 10.1111/j.1600-0404.1991.tb04955.x
DO - 10.1111/j.1600-0404.1991.tb04955.x
M3 - Article
C2 - 1772000
AN - SCOPUS:0026093779
SN - 0001-6314
VL - 84
SP - 282
EP - 285
JO - Acta Neurologica Scandinavica
JF - Acta Neurologica Scandinavica
IS - 4
ER -