Severe delayed hypersensitivity reactions to IL-1 and IL-6 inhibitors link to common HLA-DRB1*15 alleles

Medicine and Dentistry

• Allele 100%
• Eosinophilia 100%
• Interleukin 6 100%
• Interleukin 1 100%
• Delayed Hypersensitivity 100%
• Receptor Type Tyrosine Protein Phosphatase C 100%
• Drug Hypersensitivity 90%
• Human Leukocyte Antigen 54%
• Kawasaki Disease 27%
• Haplotype 18%
• Pediatrics 9%
• Silo-Filler's Disease 9%
• Alertness 9%
• Exanthem 9%
• Arthritis 9%
• Gene Frequency 9%
• Macrophage Activation Syndrome 9%
• Anakinra 9%
• Case-Control Study 9%

Immunology and Microbiology

• Interleukin 1 100%
• Allele 100%
• Interleukin 6 100%
• Delayed Hypersensitivity 100%
• Drug Hypersensitivity 100%
• Receptor Type Tyrosine Protein Phosphatase C 100%
• Human Leukocyte Antigen 60%
• Kawasaki Disease 30%
• Systemic-Onset Juvenile Idiopathic Arthritis 30%
• Haplotype 20%
• Face 10%
• Gene Frequency 10%
• Alertness 10%
• Macrophage Activation Syndrome 10%
• Anakinra 10%
• Childhood Arthritis 10%

Keyphrases

• Interleukin-1β 100%
• Eosinophilia 100%
• Delayed Hypersensitivity 100%
• Systemic Symptoms 90%
• Drug Reaction 90%
• Drug Tolerant 36%
• Kawasaki Disease 27%
• Disease Groups 18%
• New Human Leukocyte Antigen Allele 18%
• Human Leukocyte Antigen 18%
• Pediatric 9%
• Interleukin-6 9%
• Lung Disease 9%
• Allele Frequency 9%
• Clinical Data 9%
• Childhood Arthritis 9%
• Self-identification 9%
• DRB1 9%
• Macrophage Activation Syndrome 9%
• Symptom Patterns 9%
• Anakinra 9%
• Serious Reactions 9%
• ALT Elevation 9%