Severe neonatal hemolysis due to a maternal antibody to the low-frequency Rh antigen Cw

Julie May-Wewers; Jeffrey Kaiser; Ellen Kay Moore; Douglas P. Blackall

doi:10.1055/s-2006-934098

Severe neonatal hemolysis due to a maternal antibody to the low-frequency Rh antigen C^w

Julie May-Wewers, Jeffrey Kaiser, Ellen Kay Moore, Douglas P. Blackall

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

C^w is a low-frequency antigen in the Rh blood group system with a prevalence of ∼2% in whites. Although anti-C^w is not an uncommon antibody in pregnancy (0.1% incidence), clinically significant hemolytic disease of the newborn is highly unusual. We report the case of an infant with severe hyperbilirubinemia and persistent anemia due to a high-titer maternal C^w antibody. The medical literature relating to maternal C^w alloimmunization and neonatal outcome is also reviewed. In addition, recommendations are made regarding the management of pregnancies and newborns complicated by antibodies to C^w.

Original language	English (US)
Pages (from-to)	213-217
Number of pages	5
Journal	American Journal of Perinatology
Volume	23
Issue number	4
DOIs	https://doi.org/10.1055/s-2006-934098
State	Published - May 2006

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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abstract = "Cw is a low-frequency antigen in the Rh blood group system with a prevalence of ∼2% in whites. Although anti-Cw is not an uncommon antibody in pregnancy (0.1% incidence), clinically significant hemolytic disease of the newborn is highly unusual. We report the case of an infant with severe hyperbilirubinemia and persistent anemia due to a high-titer maternal Cw antibody. The medical literature relating to maternal Cw alloimmunization and neonatal outcome is also reviewed. In addition, recommendations are made regarding the management of pregnancies and newborns complicated by antibodies to Cw.",

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AU - Moore, Ellen Kay

AU - Blackall, Douglas P.

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N2 - Cw is a low-frequency antigen in the Rh blood group system with a prevalence of ∼2% in whites. Although anti-Cw is not an uncommon antibody in pregnancy (0.1% incidence), clinically significant hemolytic disease of the newborn is highly unusual. We report the case of an infant with severe hyperbilirubinemia and persistent anemia due to a high-titer maternal Cw antibody. The medical literature relating to maternal Cw alloimmunization and neonatal outcome is also reviewed. In addition, recommendations are made regarding the management of pregnancies and newborns complicated by antibodies to Cw.

AB - Cw is a low-frequency antigen in the Rh blood group system with a prevalence of ∼2% in whites. Although anti-Cw is not an uncommon antibody in pregnancy (0.1% incidence), clinically significant hemolytic disease of the newborn is highly unusual. We report the case of an infant with severe hyperbilirubinemia and persistent anemia due to a high-titer maternal Cw antibody. The medical literature relating to maternal Cw alloimmunization and neonatal outcome is also reviewed. In addition, recommendations are made regarding the management of pregnancies and newborns complicated by antibodies to Cw.

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Severe neonatal hemolysis due to a maternal antibody to the low-frequency Rh antigen C^w

Abstract

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