Sex differences in effects of cigarette smoking and 24-hr abstinence on plasma arginine vasopressin

Melissa M. Guaderrama, Elizabeth J. Corwin, Christine H. Kapelewski, Laura Cousino Klein

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The present study examined plasma arginine vasopressin (AVP) levels in 18 smokers (10 men, 8 women) and in 22 non-smokers (12 men, 10 women). Non-smokers came to the laboratory once, whereas smokers came twice: while smoking freely and following 24-hr abstinence. Plasma was collected for AVP assessment; salivary cotinine and expired carbon monoxide levels confirmed smoking status. Among non-smokers, men had higher AVP levels than did women (p< 0.05). Among smokers, however, women displayed higher AVP levels than did men both while smoking and following abstinence (p's < 0.05). Among men, smoking resulted in lower AVP levels compared to non-smoking men. In contrast, women who smoked displayed higher AVP levels compared to their non-smoking counterparts. AVP levels were not affected by 24-hr abstinence among smokers, regardless of sex, which suggests that dysregulation in AVP levels in tobacco smokers continues even following 24-hr abstinence. Findings are consistent with previous reports of elevated Th1/Th2 immune function among female smokers compared to male smokers and to male and female non-smokers. Data suggest sex-dependent AVP changes during smoking that could contribute to negative impact of smoking on cardiovascular health.

Original languageEnglish (US)
Pages (from-to)1106-1109
Number of pages4
JournalAddictive Behaviors
Issue number11
StatePublished - Nov 2011

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Toxicology
  • Psychiatry and Mental health


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