TY - JOUR
T1 - Sex differences in effects of opioid blockade on stress-induced freezing behavior
AU - Cousino Klein, Laura
AU - Popke, E. Jon
AU - Grunberg, Neil E.
N1 - Funding Information:
This work was conducted at the Uniformed Services University of the Health Sciences (USUHS) and was supported by USUHS protocol R072AR. The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Department of Defense, USUHS, the University of California, Los Angeles, the Food and Drug Administration, or the National Center for Toxicological Research. The procedures followed in this research were reviewed and approved by the USUHS Laboratory Animal Review Board. The authors thank Kevin Alvares and Stephanie Nespor for their contributions to this experiment. In addition, we thank the editor and reviewers for valuable comments on an earlier version of this manuscript.
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1998/12
Y1 - 1998/12
N2 - The present experiment examined the effects of naloxone on freezing behavior in male and female rats following stress and no-stress conditions. Twelve male and 12 female Wistar rats were exposed to 10 min of mild, unpredictable footshock stress and to a comparable no-stress condition. Immediately following stress or no-stress conditions, subjects were injected with naloxone or saline, and two independent observers measured freezing behavior. In male rats, naloxone potentiated freezing following stress but had no effect on freezing following no-stress. In females, naloxone did not affect freezing regardless of stress conditions. These results reveal a sex difference in effects of naloxone on freezing behavior and suggest that sex differences may exist with respect to the role of endogenous opioids under stress. Copyright (C) 1998 Elsevier Science Inc.
AB - The present experiment examined the effects of naloxone on freezing behavior in male and female rats following stress and no-stress conditions. Twelve male and 12 female Wistar rats were exposed to 10 min of mild, unpredictable footshock stress and to a comparable no-stress condition. Immediately following stress or no-stress conditions, subjects were injected with naloxone or saline, and two independent observers measured freezing behavior. In male rats, naloxone potentiated freezing following stress but had no effect on freezing following no-stress. In females, naloxone did not affect freezing regardless of stress conditions. These results reveal a sex difference in effects of naloxone on freezing behavior and suggest that sex differences may exist with respect to the role of endogenous opioids under stress. Copyright (C) 1998 Elsevier Science Inc.
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U2 - 10.1016/S0091-3057(98)00135-X
DO - 10.1016/S0091-3057(98)00135-X
M3 - Article
C2 - 9802836
AN - SCOPUS:0344973661
SN - 0091-3057
VL - 61
SP - 413
EP - 417
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
IS - 4
ER -