TY - JOUR
T1 - Sex differences in experimental autoimmune encephalomyelitis in multiple murine strains
AU - Papenfuss, Tracey L.
AU - Rogers, Connie J.
AU - Gienapp, Ingrid
AU - Yurrita, Maria
AU - McClain, Melanie
AU - Damico, Nicole
AU - Valo, Janie
AU - Song, Fei
AU - Whitacre, Caroline C.
N1 - Funding Information:
This study was supported by grants from the National Institute of Health (#AI43376) and the National Multiple Sclerosis Society (NMSS grant #RG3091). T.L. Papenfuss is a post-doctoral fellow of the NMSS (#FG1555-A-1)
PY - 2004/5
Y1 - 2004/5
N2 - Multiple sclerosis (MS) is more prevalent in women than men. We evaluated seven different mouse strains commonly used in the study of autoimmune diseases, for sex differences in the disease course of experimental autoimmune encephalomyelitis (EAE). Greater severity of EAE was observed in the female SJL immunized with two different peptides of myelin proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) as well as in the female ASW relative to males. Female NZW mice showed a greater incidence of EAE than males. However, male B10.PL and PL/J mice showed more severe disease than females. No sex differences were noted in the C57BL/6 or NOD strains.
AB - Multiple sclerosis (MS) is more prevalent in women than men. We evaluated seven different mouse strains commonly used in the study of autoimmune diseases, for sex differences in the disease course of experimental autoimmune encephalomyelitis (EAE). Greater severity of EAE was observed in the female SJL immunized with two different peptides of myelin proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) as well as in the female ASW relative to males. Female NZW mice showed a greater incidence of EAE than males. However, male B10.PL and PL/J mice showed more severe disease than females. No sex differences were noted in the C57BL/6 or NOD strains.
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U2 - 10.1016/j.jneuroim.2004.01.018
DO - 10.1016/j.jneuroim.2004.01.018
M3 - Article
C2 - 15081249
AN - SCOPUS:1842737784
SN - 0165-5728
VL - 150
SP - 59
EP - 69
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -