Sex differences in salivary cortisol levels following naltrexone administration

Laura Cousino Klein; Larry D. Jamner; Janel Alberts; Matthew D. Orenstein; Linda Levine; Hoyle Leigh

doi:10.1111/j.1751-9861.2000.tb00070.x

Sex differences in salivary cortisol levels following naltrexone administration

Laura Cousino Klein, Larry D. Jamner, Janel Alberts, Matthew D. Orenstein, Linda Levine, Hoyle Leigh

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Effects of endogenous opioid peptide blockade by naltrexone on salivary cortisol levels were examined in healthy men (n = 8) and women (n = 6). Participants received naltrexone (100 mg) during one laboratory session and a placebo pill during another session. Drug order was counterbalanced across participants. Saliva samples were collected 24 hr after each pill was administered. Among women, salivary cortisol levels significantly increased following naltrexone administration compared with a placebo pill. Naltrexone administration did not alter salivary cortisol levels in men. Results suggest sex differences in neuroendocrine sensitivity to opioid blockade, a finding that may hold significance with regard to the treatment of alcohol addiction with naltrexone.

Original language	English (US)
Pages (from-to)	144-153
Number of pages	10
Journal	Journal of Applied Biobehavioral Research
Volume	5
Issue number	2
DOIs	https://doi.org/10.1111/j.1751-9861.2000.tb00070.x
State	Published - 2000

All Science Journal Classification (ASJC) codes

Cultural Studies
Experimental and Cognitive Psychology
Clinical Psychology
Social Sciences (miscellaneous)

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title = "Sex differences in salivary cortisol levels following naltrexone administration",

abstract = "Effects of endogenous opioid peptide blockade by naltrexone on salivary cortisol levels were examined in healthy men (n = 8) and women (n = 6). Participants received naltrexone (100 mg) during one laboratory session and a placebo pill during another session. Drug order was counterbalanced across participants. Saliva samples were collected 24 hr after each pill was administered. Among women, salivary cortisol levels significantly increased following naltrexone administration compared with a placebo pill. Naltrexone administration did not alter salivary cortisol levels in men. Results suggest sex differences in neuroendocrine sensitivity to opioid blockade, a finding that may hold significance with regard to the treatment of alcohol addiction with naltrexone.",

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AU - Klein, Laura Cousino

AU - Jamner, Larry D.

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AU - Levine, Linda

AU - Leigh, Hoyle

PY - 2000

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N2 - Effects of endogenous opioid peptide blockade by naltrexone on salivary cortisol levels were examined in healthy men (n = 8) and women (n = 6). Participants received naltrexone (100 mg) during one laboratory session and a placebo pill during another session. Drug order was counterbalanced across participants. Saliva samples were collected 24 hr after each pill was administered. Among women, salivary cortisol levels significantly increased following naltrexone administration compared with a placebo pill. Naltrexone administration did not alter salivary cortisol levels in men. Results suggest sex differences in neuroendocrine sensitivity to opioid blockade, a finding that may hold significance with regard to the treatment of alcohol addiction with naltrexone.

AB - Effects of endogenous opioid peptide blockade by naltrexone on salivary cortisol levels were examined in healthy men (n = 8) and women (n = 6). Participants received naltrexone (100 mg) during one laboratory session and a placebo pill during another session. Drug order was counterbalanced across participants. Saliva samples were collected 24 hr after each pill was administered. Among women, salivary cortisol levels significantly increased following naltrexone administration compared with a placebo pill. Naltrexone administration did not alter salivary cortisol levels in men. Results suggest sex differences in neuroendocrine sensitivity to opioid blockade, a finding that may hold significance with regard to the treatment of alcohol addiction with naltrexone.

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Sex differences in salivary cortisol levels following naltrexone administration

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