TY - JOUR
T1 - Sexual Satisfaction and Cardiovascular Disease
T2 - The Women's Health Initiative
AU - McCall-Hosenfeld, Jennifer
AU - Freund, Karen M.
AU - Legault, Claudine
AU - Jaramillo, Sarah A.
AU - Cochrane, Barbara B.
AU - Manson, Jo Ann E.
AU - Wenger, Nanette K.
AU - Eaton, Charles B.
AU - McNeeley, S. Gene
AU - Rodriguez, Beatriz L.
AU - Bonds, Denise
N1 - Funding Information:
The Women’s Health Initiative program was funded by the National Heart, Lung and Blood Institute of the National Institutes of Health, U.S. Department of Health and Human Services. Dr. McCall-Hosenfeld was supported by a Department of Veterans Affairs Special Fellowship in the Health Issues of Women Veterans.
Funding Information:
The WHI program is funded by the National Heart, Lung and Blood Institute, US Department of Health and Human Services. The funding organization had representation on the steering committee, which governed the design and conduct of the study, the interpretation of the data, and the preparation and approval of manuscript. The National Heart, Lung, and Blood Institute Program Office reviewed the manuscript before publication.
PY - 2008/4
Y1 - 2008/4
N2 - Background: Sexual dysfunction in some men is predictive of occult cardiovascular disease. We investigated whether dissatisfaction with sexual activity, a domain of female sexual dysfunction, is associated with prevalent and incident cardiovascular disease in postmenopausal women. Methods: Data from the Women′s Health Initiative-Observational Study were used. Subjects who were sexually active in the past year were classified at baseline as sexually satisfied or dissatisfied. We performed multiple logistic regression analyses modeling baseline cardiovascular conditions including myocardial infarction, stroke, coronary revascularization, peripheral arterial disease, congestive heart failure, and angina. We then created Cox proportional hazards models to determine hazard ratios for incident cardiovascular disease by baseline sexual dissatisfaction status. Results: Dissatisfaction with sexual activity at baseline was significantly associated with prevalent peripheral arterial disease (odds ratio 1.44, 95% confidence interval, 1.15-1.84), but not prevalent myocardial infarction, stroke, coronary revascularization including coronary artery bypass graft and percutaneous transluminal coronary angioplasty, or a composite cardiovascular disease variable. The odds of baseline angina were decreased among those reporting sexual dissatisfaction at baseline (odds ratio 0.77, 95% confidence interval, 0.66-0.86). In both unadjusted and adjusted analyses, dissatisfaction with sexual activity was not significantly related to an increased hazard of any cardiovascular disease. Conclusions: Dissatisfaction with sexual activity was modestly associated with an increased prevalence of peripheral arterial disease, even after controlling for smoking status. However, dissatisfaction did not predict incident cardiovascular disease. Although this may represent insensitivity of the sexual satisfaction construct to measure sexual dysfunction in women, it might be due to physiological differences in sexual functioning between men and women.
AB - Background: Sexual dysfunction in some men is predictive of occult cardiovascular disease. We investigated whether dissatisfaction with sexual activity, a domain of female sexual dysfunction, is associated with prevalent and incident cardiovascular disease in postmenopausal women. Methods: Data from the Women′s Health Initiative-Observational Study were used. Subjects who were sexually active in the past year were classified at baseline as sexually satisfied or dissatisfied. We performed multiple logistic regression analyses modeling baseline cardiovascular conditions including myocardial infarction, stroke, coronary revascularization, peripheral arterial disease, congestive heart failure, and angina. We then created Cox proportional hazards models to determine hazard ratios for incident cardiovascular disease by baseline sexual dissatisfaction status. Results: Dissatisfaction with sexual activity at baseline was significantly associated with prevalent peripheral arterial disease (odds ratio 1.44, 95% confidence interval, 1.15-1.84), but not prevalent myocardial infarction, stroke, coronary revascularization including coronary artery bypass graft and percutaneous transluminal coronary angioplasty, or a composite cardiovascular disease variable. The odds of baseline angina were decreased among those reporting sexual dissatisfaction at baseline (odds ratio 0.77, 95% confidence interval, 0.66-0.86). In both unadjusted and adjusted analyses, dissatisfaction with sexual activity was not significantly related to an increased hazard of any cardiovascular disease. Conclusions: Dissatisfaction with sexual activity was modestly associated with an increased prevalence of peripheral arterial disease, even after controlling for smoking status. However, dissatisfaction did not predict incident cardiovascular disease. Although this may represent insensitivity of the sexual satisfaction construct to measure sexual dysfunction in women, it might be due to physiological differences in sexual functioning between men and women.
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U2 - 10.1016/j.amjmed.2007.11.013
DO - 10.1016/j.amjmed.2007.11.013
M3 - Article
C2 - 18374688
AN - SCOPUS:40949083831
SN - 0002-9343
VL - 121
SP - 295
EP - 301
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 4
ER -
