TY - JOUR
T1 - Shared and distinct functions of RAGS and ELF-1 in guiding retinal axons
AU - Monschau, Bruno
AU - Kremoser, Claus
AU - Ohta, Kunimasa
AU - Tanaka, Hideaki
AU - Kaneko, Tomomi
AU - Yamada, Tomoko
AU - Handwerker, Claudia
AU - Hornberger, Martin R.
AU - Löschinger, Jürgen
AU - Pasquale, Elena B.
AU - Siever, Doyle A.
AU - Verderame, Michael F.
AU - Müller, Bernhard K.
AU - Bonhoeffer, Friedrich
AU - Drescher, Uwe
PY - 1997/3/17
Y1 - 1997/3/17
N2 - Two ligands for Eph-related receptor tyrosine kinases, RAGS and ELF-1, have been implicated in the control of development of the retinotectal projection. Both molecules are expressed in overlapping gradients in the tectum, the target area of retinal ganglion cell axons. In two in vitro assays ELF-1 is shown to have a repellent axon guidance function for temporal, but apparently not for nasal axons. RAGS on the other hand is repellent for both types of axons, though to different degrees. Thus, RAGS and ELF-1 share some and differ in other properties. The biological activities of these molecules correlate with the strength of interaction with their receptors expressed on RGC axons. The meaning of these findings for guidance of retinal axons in the tectum is discussed.
AB - Two ligands for Eph-related receptor tyrosine kinases, RAGS and ELF-1, have been implicated in the control of development of the retinotectal projection. Both molecules are expressed in overlapping gradients in the tectum, the target area of retinal ganglion cell axons. In two in vitro assays ELF-1 is shown to have a repellent axon guidance function for temporal, but apparently not for nasal axons. RAGS on the other hand is repellent for both types of axons, though to different degrees. Thus, RAGS and ELF-1 share some and differ in other properties. The biological activities of these molecules correlate with the strength of interaction with their receptors expressed on RGC axons. The meaning of these findings for guidance of retinal axons in the tectum is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0031003116&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031003116&partnerID=8YFLogxK
U2 - 10.1093/emboj/16.6.1258
DO - 10.1093/emboj/16.6.1258
M3 - Article
C2 - 9135142
AN - SCOPUS:0031003116
SN - 0261-4189
VL - 16
SP - 1258
EP - 1267
JO - EMBO Journal
JF - EMBO Journal
IS - 6
ER -