Shell cross-linked nanoparticles designed to target angiogenic blood vessels via α vβ 3 receptor-ligand interactions

Dipanjan Pan; Jeffrey L. Turner; Karen L. Wooley

doi:10.1021/ma048824e

Shell cross-linked nanoparticles designed to target angiogenic blood vessels via α _vβ ₃ receptor-ligand interactions

Dipanjan Pan, Jeffrey L. Turner, Karen L. Wooley

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

The design, synthesis, and characterization of a novel polymeric nanostructured material bearing surface-attached integrin antagonists are demonstrated. The covalent coupling of a complex and biologically active small molecule to a well-defined nanostructured material combines the elegance of synthetic organic chemistry with the state-of-the-art polymer chemistry. This unique material offers potential in targeting to tumor neovasculature and delivery of diagnostic and therapeutic agents.

Original language	English (US)
Pages (from-to)	7109-7115
Number of pages	7
Journal	Macromolecules
Volume	37
Issue number	19
DOIs	https://doi.org/10.1021/ma048824e
State	Published - Sep 21 2004

All Science Journal Classification (ASJC) codes

Organic Chemistry
Polymers and Plastics
Inorganic Chemistry
Materials Chemistry

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10.1021/ma048824e

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title = "Shell cross-linked nanoparticles designed to target angiogenic blood vessels via α vβ 3 receptor-ligand interactions",

abstract = "The design, synthesis, and characterization of a novel polymeric nanostructured material bearing surface-attached integrin antagonists are demonstrated. The covalent coupling of a complex and biologically active small molecule to a well-defined nanostructured material combines the elegance of synthetic organic chemistry with the state-of-the-art polymer chemistry. This unique material offers potential in targeting to tumor neovasculature and delivery of diagnostic and therapeutic agents.",

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AU - Turner, Jeffrey L.

AU - Wooley, Karen L.

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Y1 - 2004/9/21

N2 - The design, synthesis, and characterization of a novel polymeric nanostructured material bearing surface-attached integrin antagonists are demonstrated. The covalent coupling of a complex and biologically active small molecule to a well-defined nanostructured material combines the elegance of synthetic organic chemistry with the state-of-the-art polymer chemistry. This unique material offers potential in targeting to tumor neovasculature and delivery of diagnostic and therapeutic agents.

AB - The design, synthesis, and characterization of a novel polymeric nanostructured material bearing surface-attached integrin antagonists are demonstrated. The covalent coupling of a complex and biologically active small molecule to a well-defined nanostructured material combines the elegance of synthetic organic chemistry with the state-of-the-art polymer chemistry. This unique material offers potential in targeting to tumor neovasculature and delivery of diagnostic and therapeutic agents.

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Shell cross-linked nanoparticles designed to target angiogenic blood vessels via α _vβ ₃ receptor-ligand interactions

Abstract

All Science Journal Classification (ASJC) codes

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