@article{7e2c2500ac3f45898f5e20c932a4f3ce,
title = "SHIRAZ: An automated histology image annotation system for Zebrafish phenomics",
abstract = "Histological characterization is used in clinical and research contexts as a highly sensitive method for detecting the morphological features of disease and abnormal gene function. Histology has recently been accepted as a phenotyping method for the forthcoming Zebrafish Phenome Project, a large-scale community effort to characterize the morphological, physiological, and behavioral phenotypes resulting from the mutations in all known genes in the zebrafish genome. In support of this project, we present a novel content-based image retrieval system for the automated annotation of images containing histological abnormalities in the developing eye of the larval zebrafish.",
author = "Canada, {Brian A.} and Thomas, {Georgia K.} and Cheng, {Keith C.} and Wang, {James Z.}",
note = "Funding Information: Acknowledgements The work of B. A. Canada was supported by the Penn State Academic Computing Fellowship as well as the Penn State Clinical and Translational Sciences Institute. This work was also supported by NIH NCRR grant R24 RR01744 for the Zebrafish Atlas, as well as by grants from the Jake Gittlen Cancer Research Foundation and Pennsylvania Tobacco Settlement Funds to K. C. Cheng and a Penn State Graduate fellowship to G. K. Thomas. J. Z. Wang is supported by NSF Grant No. 0347148; in addition, NSF has provided computation infrastructure through Grant Nos. 0219272 and 0821527. The authors wish to thank the following current and former members of the Jake Gittlen Cancer Research Foundation for their invaluable assistance over the course of this project: Steven Peckins, for technical support in the processing of very high resolution images; Kelsey Bauer, for pre-segmentation hand labeling of histological specimens; as well as Jean Copper, Christina Foutz, and Lynn Budgeon for their efforts in preparing and digitizing the source microscope slides. Finally, the authors thank Yanxi Liu (Penn State Department of Computer Science and Engineering) for helpful discussions regarding computational symmetry.",
year = "2011",
month = jan,
doi = "10.1007/s11042-010-0638-4",
language = "English (US)",
volume = "51",
pages = "401--440",
journal = "Multimedia Tools and Applications",
issn = "1380-7501",
publisher = "Springer",
number = "2",
}