TY - JOUR
T1 - Short communication
T2 - Genetic variations of SLC2A9 in relation to Parkinson's disease
AU - Gao, Jianjun
AU - Xu, Hong
AU - Huang, Xuemei
AU - Chen, Honglei
N1 - Funding Information:
This study was supported by the intramural research program of the NIH, the National Institute of Environmental Health Sciences (Z01-ES-101986), and NIH extramural grant to Dr. Huang (NS06722).
PY - 2013/2/19
Y1 - 2013/2/19
N2 - Background: Epidemiological studies showed that higher plasma urate was associated with lower risk for Parkinson's disease (PD) and slower disease progression. Recent genome-wide association studies (GWAS) consistently showed that several single nucleotide polymorphisms (SNPs) in the solute carrier family 2 member 9 gene (SLC2A9 ) were associated with plasma urate concentration and the risk of gout.Methods: We conducted a case-control study to examine twelve tag SNPs of the SLC2A9 gene in relation to PD among 788 cases and 911 controls of European ancestry. Odds ratios (OR) and 95% confidence intervals (CI) were derived from logistic regression models, adjusting for age, sex, smoking and caffeine consumption.Results: These SNPs were all in linkage disequilibrium (R2 > 0.7). None of them were associated with PD risk. Among women, however, there was a suggestion that the presence of the minor allele of one SNP (rs7442295) was related to a small increase in PD risk [OR (95% CI) = 1.48 (1.01-2.16)].Conclusion: This study provides little support for genetic variations of SLC2A9 and PD risk.
AB - Background: Epidemiological studies showed that higher plasma urate was associated with lower risk for Parkinson's disease (PD) and slower disease progression. Recent genome-wide association studies (GWAS) consistently showed that several single nucleotide polymorphisms (SNPs) in the solute carrier family 2 member 9 gene (SLC2A9 ) were associated with plasma urate concentration and the risk of gout.Methods: We conducted a case-control study to examine twelve tag SNPs of the SLC2A9 gene in relation to PD among 788 cases and 911 controls of European ancestry. Odds ratios (OR) and 95% confidence intervals (CI) were derived from logistic regression models, adjusting for age, sex, smoking and caffeine consumption.Results: These SNPs were all in linkage disequilibrium (R2 > 0.7). None of them were associated with PD risk. Among women, however, there was a suggestion that the presence of the minor allele of one SNP (rs7442295) was related to a small increase in PD risk [OR (95% CI) = 1.48 (1.01-2.16)].Conclusion: This study provides little support for genetic variations of SLC2A9 and PD risk.
UR - http://www.scopus.com/inward/record.url?scp=84883602992&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883602992&partnerID=8YFLogxK
U2 - 10.1186/2047-9158-2-5
DO - 10.1186/2047-9158-2-5
M3 - Article
C2 - 23422251
AN - SCOPUS:84883602992
SN - 2047-9158
VL - 2
JO - Translational Neurodegeneration
JF - Translational Neurodegeneration
IS - 1
M1 - 5
ER -