Sialidase activity of oncogenic cells transformed by herpes simplex virus

C. L. Schengrund, R. Duff, A. Rosenberg

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Sialidase in normal nononcogenic hamster embryo fibroblasts was not active toward added disialo- and trisialoganglioside, but all transformed lines of hamster embryo fibroblasts studied had sialidase active toward added ganglioside substrate. The levels of exogenous sialidase activity suggested a parallel trend in the amount of this activity and the degree of oncogenicity of the transformed cells. Exogenous sialidase activity in a weakly oncogenic cell line was found to increase after passage of the cells into hamsters and isolation and cell culture of the resulting tumors which gave rise to a cell line of relatively high oncogenicity.

Original languageEnglish (US)
Pages (from-to)595-599
Number of pages5
Issue number2
StatePublished - Apr 1974

All Science Journal Classification (ASJC) codes

  • Virology


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