Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease

Timothy D. O’connell; Katherine A. Murphy; Naixin Zhang; Sara J. Puccini; Chastity L. Healy; Brian A. Harsch; Michael J. Zhang; Gregory C. Shearer

doi:10.1152/physiol.00007.2022

Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease

Timothy D. O’connell, Katherine A. Murphy, Naixin Zhang, Sara J. Puccini, Chastity L. Healy, Brian A. Harsch, Michael J. Zhang, Gregory C. Shearer

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-poly-unsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation of cardiometabolic disease.

Original language	English (US)
Pages (from-to)	311-322
Number of pages	12
Journal	Physiology
Volume	37
Issue number	6
DOIs	https://doi.org/10.1152/physiol.00007.2022
State	Published - Nov 2022

All Science Journal Classification (ASJC) codes

Physiology

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10.1152/physiol.00007.2022

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title = "Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease",

abstract = "A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-poly-unsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation of cardiometabolic disease.",

author = "O{\textquoteright}connell, {Timothy D.} and Murphy, {Katherine A.} and Naixin Zhang and Puccini, {Sara J.} and Healy, {Chastity L.} and Harsch, {Brian A.} and Zhang, {Michael J.} and Shearer, {Gregory C.}",

note = "Publisher Copyright: {\textcopyright} 2022 Int. Union Physiol. Sci./Am. Physiol. Soc.",

year = "2022",

month = nov,

doi = "10.1152/physiol.00007.2022",

language = "English (US)",

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publisher = "American Physiological Society",

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AU - O’connell, Timothy D.

AU - Murphy, Katherine A.

AU - Zhang, Naixin

AU - Puccini, Sara J.

AU - Healy, Chastity L.

AU - Harsch, Brian A.

AU - Zhang, Michael J.

AU - Shearer, Gregory C.

PY - 2022/11

Y1 - 2022/11

N2 - A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-poly-unsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation of cardiometabolic disease.

AB - A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-poly-unsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation of cardiometabolic disease.

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EP - 322

JO - Physiology

JF - Physiology

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ER -

Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease

Abstract

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