Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease

Timothy D. O’connell, Katherine A. Murphy, Naixin Zhang, Sara J. Puccini, Chastity L. Healy, Brian A. Harsch, Michael J. Zhang, Gregory C. Shearer

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-poly-unsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation of cardiometabolic disease.

Original languageEnglish (US)
Pages (from-to)311-322
Number of pages12
Issue number6
StatePublished - Nov 2022

All Science Journal Classification (ASJC) codes

  • Physiology


Dive into the research topics of 'Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease'. Together they form a unique fingerprint.

Cite this