Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease

Timothy D. O’connell; Katherine A. Murphy; Naixin Zhang; Sara J. Puccini; Chastity L. Healy; Brian A. Harsch; Michael J. Zhang; Gregory C. Shearer

doi:10.1152/physiol.00007.2022

Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease

Timothy D. O’connell
, Katherine A. Murphy
, Naixin Zhang
, Sara J. Puccini
, Chastity L. Healy
, Brian A. Harsch
, Michael J. Zhang
, Gregory C. Shearer

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-poly-unsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation of cardiometabolic disease.

Original language	English (US)
Pages (from-to)	311-322
Number of pages	12
Journal	Physiology
Volume	37
Issue number	6
DOIs	https://doi.org/10.1152/physiol.00007.2022
State	Published - Nov 2022

All Science Journal Classification (ASJC) codes

Physiology

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10.1152/physiol.00007.2022

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@article{e11f377de3454a88b1938fd8aad46c87,

title = "Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease",

abstract = "A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-poly-unsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation of cardiometabolic disease.",

author = "O{\textquoteright}connell, \{Timothy D.\} and Murphy, \{Katherine A.\} and Naixin Zhang and Puccini, \{Sara J.\} and Healy, \{Chastity L.\} and Harsch, \{Brian A.\} and Zhang, \{Michael J.\} and Shearer, \{Gregory C.\}",

note = "Publisher Copyright: {\textcopyright} 2022 Int. Union Physiol. Sci./Am. Physiol. Soc.",

year = "2022",

month = nov,

doi = "10.1152/physiol.00007.2022",

language = "English (US)",

volume = "37",

pages = "311--322",

journal = "Physiology",

issn = "1548-9213",

publisher = "American Physiological Society",

number = "6",

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TY - JOUR

T1 - Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease

AU - O’connell, Timothy D.

AU - Murphy, Katherine A.

AU - Zhang, Naixin

AU - Puccini, Sara J.

AU - Healy, Chastity L.

AU - Harsch, Brian A.

AU - Zhang, Michael J.

AU - Shearer, Gregory C.

PY - 2022/11

Y1 - 2022/11

N2 - A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-poly-unsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation of cardiometabolic disease.

AB - A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-poly-unsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation of cardiometabolic disease.

UR - https://www.scopus.com/pages/publications/85139571494

UR - https://www.scopus.com/pages/publications/85139571494#tab=citedBy

U2 - 10.1152/physiol.00007.2022

DO - 10.1152/physiol.00007.2022

M3 - Review article

C2 - 35944007

AN - SCOPUS:85139571494

SN - 1548-9213

VL - 37

SP - 311

EP - 322

JO - Physiology

JF - Physiology

IS - 6

ER -

Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease

Abstract

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