TY - GEN
T1 - Silicon nanopore membrane technology for an implantable artificial kidney
AU - Roy, Shuvo
AU - Dubnisheva, Anna
AU - Eldridge, Abigail
AU - Fleischman, Aaron J.
AU - Goldman, Kenneth G.
AU - Humes, H. David
AU - Zydney, Andrew L.
AU - Fissell, William H.
PY - 2009
Y1 - 2009
N2 - High performance silicon nanoporous membranes have been developed to investigate the feasibility of an implantable bioartificial kidney. The nanoscale pore size is defined by the thickness of a sacrificial layer of silicon dioxide (SiO2), which is grown by thermal oxidation down to 5 nm with 1% variation. Standardized test protocols to examine biocompatibility revealed that silicon and related MEMS materials did not exhibit any evidence of cytotoxicity or hemolysis. Surface modification with polyethylene glycol (PEG) monolayers reduced adsorption of bovine serum albumin (BSA) onto MEMS surfaces to ∼4% of positive control. PEG-modified membranes exhibited size-dependent rejection of Ficoll 70, a spherical probe solute, dissolved in bovine whole blood. Prolonged hemofiltration revealed constant membrane flux and consistent molecular selectivity for >72 hours.
AB - High performance silicon nanoporous membranes have been developed to investigate the feasibility of an implantable bioartificial kidney. The nanoscale pore size is defined by the thickness of a sacrificial layer of silicon dioxide (SiO2), which is grown by thermal oxidation down to 5 nm with 1% variation. Standardized test protocols to examine biocompatibility revealed that silicon and related MEMS materials did not exhibit any evidence of cytotoxicity or hemolysis. Surface modification with polyethylene glycol (PEG) monolayers reduced adsorption of bovine serum albumin (BSA) onto MEMS surfaces to ∼4% of positive control. PEG-modified membranes exhibited size-dependent rejection of Ficoll 70, a spherical probe solute, dissolved in bovine whole blood. Prolonged hemofiltration revealed constant membrane flux and consistent molecular selectivity for >72 hours.
UR - http://www.scopus.com/inward/record.url?scp=71449104198&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=71449104198&partnerID=8YFLogxK
U2 - 10.1109/SENSOR.2009.5285603
DO - 10.1109/SENSOR.2009.5285603
M3 - Conference contribution
AN - SCOPUS:71449104198
SN - 9781424441938
T3 - TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
SP - 755
EP - 760
BT - TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
T2 - TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Y2 - 21 June 2009 through 25 June 2009
ER -