Simulation of earthquake-induced slope deformation using a three dimensional smoothed particle hydrodynamics (SPH) model is presented in this study. A constitutive model that combines the isotropic hardening/softening Drucker-Prager plasticity and the modified Kondner and Zelasko model is implemented into the SPH formulations. The developed model accounts for the effects of nonlinear soil behavior during cyclic loading, strain hardening/softening during sliding, and dynamic response of the slope and sliding mass, which are not explicitly considered in the Newmark-type analyses widely used in current research and practice. The developed model is validated against a readily available and welldocumented model slope test on a shaking table. Excellent agreement is observed between the model-simulated and experiment-measured records of displacement at various locations inside the model slope. It is thus suggested that the developed model may be utilized to more reliably predict earthquake-induced slope deformations.