Simultaneous MEG and EEG source analysis

H. M. Huizenga, T. L. Van Zuijen, D. J. Heslenfeld, P. C.M. Molenaar

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


A method is described to derive source and conductivity estimates in a simultaneous MEG and EEG source analysis. In addition the covariance matrix of the estimates is derived. Simulation studies with a concentric spheres model and a more realistic boundary element model indicate that this method has several advantages, even if only a few EEG sensors are added to a MEG configuration. First, a simultaneous analysis profits from the 'preferred' location directions of MEG and EEG. Second, deep sources can be estimated quite accurately, which is an advantage compared to MEG. Third, superficial sources profit from accurate MEG location and from accurate EEG moment. Fourth, the radial source component can be estimated, which is an advantage compared to MEG. Fifth, the conductivities can be estimated. It is shown that conductivity estimation gives a substantial increase in precision, even if the conductivities are not identified appropriately. An illustrative analysis of empirical data supports these findings.

Original languageEnglish (US)
Pages (from-to)1737-1751
Number of pages15
JournalPhysics in Medicine and Biology
Issue number7
StatePublished - 2001

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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