TY - JOUR
T1 - Single agent maintenance therapy for advanced stage non-small cell lung cancer
T2 - A meta-analysis
AU - Behera, Madhusmita
AU - Owonikoko, Taofeek K.
AU - Chen, Zhengjia
AU - Kono, Scott A.
AU - Khuri, Fadlo R.
AU - Belani, Chandra P.
AU - Ramalingam, Suresh S.
PY - 2012/8
Y1 - 2012/8
N2 - Background: Maintenance therapy is a new treatment paradigm for advanced non-small cell lung cancer (NSCLC). We conducted a meta-analysis of randomized studies with single agent maintenance therapy. Methods: An electronic literature search of public databases (MEDLINE, EMBASE, Cochrane library) and manual search of relevant conference proceedings was performed. A formal meta-analysis was conducted using Comprehensive Meta Analysis software (Version 2.0). Outcome data were pooled and reported as hazard ratio (HR). The primary outcome of interest was overall survival (OS) and secondary outcome was progression free survival (PFS). Results: Twelve studies were included (5 meeting abstracts, 7 full manuscripts) with a total of 4286 patients (maintenance arm/control arm - 2449/1837, median age 61. years, males - 69%). The OS (HR 0.86, 95% confidence intervals [CI] 0.80-0.92; P= 0.0003) and PFS (HR 0.80, 95% CI 0.77-0.84; P<0.0001) were superior with maintenance therapy. 'Switch' maintenance was associated with significant OS and PFS improvement (OS HR 0.84, 95% CI 0.77-0.91; P= 0.00026; PFS HR 0.62, 95% CI 0.57-0.67; P<0.0001). Despite a modest improvement in PFS (HR 0.90, 95%CI 0.85-0.95; P= 0.007), "continuation" maintenance was not associated with survival benefit (HR 0.927, 95%CI 0.78-1.09; P= 0.33). Improvements in OS and PFS were observed with both EGFR-targeted agents (HR 0.83, 95% CI 0.74-0.92; P= 0.004; HR 0.64, 95% CI 0.58-0.71 P<0.0001) and cytotoxic agents (HR 0.89, 95% CI 0.80-0.98; P= 0.018; HR 0.85, 95% CI 0.80-0.89; P<0.0001). Conclusions: Single agent maintenance therapy improves overall survival, though statistical significance was only noted with 'switch' maintenance.
AB - Background: Maintenance therapy is a new treatment paradigm for advanced non-small cell lung cancer (NSCLC). We conducted a meta-analysis of randomized studies with single agent maintenance therapy. Methods: An electronic literature search of public databases (MEDLINE, EMBASE, Cochrane library) and manual search of relevant conference proceedings was performed. A formal meta-analysis was conducted using Comprehensive Meta Analysis software (Version 2.0). Outcome data were pooled and reported as hazard ratio (HR). The primary outcome of interest was overall survival (OS) and secondary outcome was progression free survival (PFS). Results: Twelve studies were included (5 meeting abstracts, 7 full manuscripts) with a total of 4286 patients (maintenance arm/control arm - 2449/1837, median age 61. years, males - 69%). The OS (HR 0.86, 95% confidence intervals [CI] 0.80-0.92; P= 0.0003) and PFS (HR 0.80, 95% CI 0.77-0.84; P<0.0001) were superior with maintenance therapy. 'Switch' maintenance was associated with significant OS and PFS improvement (OS HR 0.84, 95% CI 0.77-0.91; P= 0.00026; PFS HR 0.62, 95% CI 0.57-0.67; P<0.0001). Despite a modest improvement in PFS (HR 0.90, 95%CI 0.85-0.95; P= 0.007), "continuation" maintenance was not associated with survival benefit (HR 0.927, 95%CI 0.78-1.09; P= 0.33). Improvements in OS and PFS were observed with both EGFR-targeted agents (HR 0.83, 95% CI 0.74-0.92; P= 0.004; HR 0.64, 95% CI 0.58-0.71 P<0.0001) and cytotoxic agents (HR 0.89, 95% CI 0.80-0.98; P= 0.018; HR 0.85, 95% CI 0.80-0.89; P<0.0001). Conclusions: Single agent maintenance therapy improves overall survival, though statistical significance was only noted with 'switch' maintenance.
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U2 - 10.1016/j.lungcan.2012.03.019
DO - 10.1016/j.lungcan.2012.03.019
M3 - Article
C2 - 22546678
AN - SCOPUS:84863785946
SN - 0169-5002
VL - 77
SP - 331
EP - 338
JO - Lung Cancer
JF - Lung Cancer
IS - 2
ER -