Single cell detection with driven magnetic beads

B. H. McNaughton, R. R. Agayan, V. A. Stoica, R. Clarke, R. Kopelman

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Shifts in the nonlinear rotational frequency of magnetic beads (microspheres) offer a new and dynamic approach for the detection of single cells. We present the first demonstration of this capability by measuring the changes in the nonlinear rotational frequency of magnetic beads driven by an external magnetic field. The presence of an Escherichia coli bacterium on the surface of a 2.0 μm magnetic bead affects the drag of the system, thus changing the nonlinear rotation rate. Measurement of this rotational frequency is straight-forward utilizing standard microscopy techniques.

Original languageEnglish (US)
Title of host publicationFunctionalized Nanoscale Materials, Devices and Systems
EditorsA. Vaseashta, I.N. Mihailescu
Number of pages6
StatePublished - 2008

Publication series

NameNATO Science for Peace and Security Series B: Physics and Biophysics
ISSN (Print)1874-6500

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • General Physics and Astronomy
  • Electrical and Electronic Engineering


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